Zyflamend review and side effects, dosage, benefit, New Chapter information and review of latest published studies
April 1 2018 by
Ray Sahelian, M.D.

Zyflamend is a combination of several herbal extracts. Unlike many herbal products on the market, the makers of this combination formula have actually gone through the trouble of conducting tests on this product. It is not easy to do such studies. They take a lot of time and planning, and they are expensive. Some of the early research has shown promising results. Until several long term human studies are done we won't know exactly what kind of an effect a Zyflamend supplement will have on human health and disease.
Prostate gland studies
In vitro studies shows it suppresses the growth of prostate cancer cells and induces prostate cancer cells to self-destruct via a process called apoptosis. Zyflamend has the ability, in culture at least, to reduce prostate cancer cell growth. But, will the same benefit occur in humans when it is taken as a supplement? I don't know.

This herbal blend also has some anti-inflammatory potential.

Cancer Prev Res (Phila). 2013. Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice. In postmenopausal women, obesity is a risk factor for the development of hormone receptor-positive breast cancer driven by estrogen. After menopause, aromatization of androgen precursors in adipose tissue is a major synthetic source of estrogen. Recently, in mouse models and women, we identified an obesity-inflammation-aromatase axis. This obesity-induced inflammation is characterized by crown-like structures (CLS) consisting of dead adipocytes encircled by macrophages in breast white adipose tissue. CLS occur in association with NF-κB activation, elevated levels of proinflammatory mediators, and increased aromatase expression. Saturated fatty acids released from adipocytes have been linked to obesity-related white adipose tissue inflammation. Here we found that stearic acid, a prototypic saturated fatty acid, stimulated Akt-dependent activation of NF-κB resulting in increased levels of proinflammatory mediators [TNF-α, interleukin (IL)-1β, COX-2] in macrophages leading, in turn, to the induction of aromatase. Several polyphenols (resveratrol, curcumin, epigallocatechin gallate) blocked these inductive effects of stearic acid. Zyflamend, a widely used polyherbal preparation that contains numerous polyphenols, possessed similar suppressive effects. In a mouse model of obesity, treatment with Zyflamend suppressed levels of phospho-Akt, NF-κB binding activity, proinflammatory mediators, and aromatase in the mammary gland. Collectively, these results suggest that targeting the activation of NF-κB is a promising approach for reducing levels of proinflammatory mediators and aromatase in inflamed mouse mammary tissue. Further investigation in obese women is warranted.

Heart disease
Q. I Had a heart attack and a stent was put in to hold me till bypass surgery. The doctors did not know anything about this product as far as my heart so they told me to stop taking it. Had bypass 5 weeks ago and have started taking it again to relieve my joint discomfort. Is there any concern about taking this product again as far as heart goes. If you have any research on this could you send it to me. I have an appointment with my heart doctor and would like to have something to show him so I can keep taking Zyflamend.
   A. I am not aware of specific studies regarding this herbal formula and heart disease or heart attack or stent placement. It does have many health benefits that could be of use for cardiac patients but not enough human research is available to know for certain.

buy Zyflamend pills, New Chapter
Buy Zyflamend capsules

This product contains the following herbs and others: Basil, Turmeric, Ginger, Green tea, Rosemary, Hu Zhang, Barberry, Oregano, and Scullcap.

Supplement Facts
Serving Size: 2 Capsules
Servings Per Container: 60
  Amount Per Serving %DV
Rosemary (Rosmarinus officinalis) (leaf)
100 mg supercritical extract and 50 mg hydroethanolic extract
150 mg *
Turmeric (Curcuma longa) (rhizome)
10 mg organic supercritical extract and 100 mg hydroethanolic extract
110 mg *
Ginger extract offers numerous beneficial constituents.)
54 mg organic supercritical extract and 46 mg hydroethanolic extract
100 mg *
Basil (Ocimum sanctum) contains ursolic acid, which may enhances detoxification and support the inflammation response.
Hydroethanolic extract
100 mg *
Organic Green Tea (Camellia sinensis) (leaf) extract 100 mg *
Hu Zhang (Polygonum cuspidatum) (root and rhizome)
Hydroethanolic extract
80 mg *
Chinese Goldthread (Coptis chinensis) (root) extract 40 mg *
Barberry (Berberis vulgaris) (root)
Hydroethanolic extract
40 mg *
Organic Oregano (Origanum vulgare) (leaf)
Supercritical extract
40 mg *
Chinese Skullcap (Scutellaria baicalensis) (root) extract 20 mg *
* Daily Value (DV) not established

Q. Can Zyflamend supplement be taken daily forever?
   A. It's difficult to know since long term human trials have not been done. The herbs in this product appear to have health promoting potential, but to be cautious, we suggest taking breaks from use, although there are no accepted guidelines on how often and how long these breaks should be.

This product has the following phytonutrient ingredients:
This polyherbal preparation was designed based on constituents that exhibit antiproliferative,
antiinflammatory, antioxidant, antiangiogenic, and apoptotic activities through mechanisms that are not yet well defined.

Turmeric is a unique curcumin phytonutrient complex that may have additional benefit when combined with green tea polyphenols.

Green tea has potent polyphenols and has been praised highly by scientists and the media.

Rosemary herb is starting to become more popular.

Hu Zhang: (Polygonum cuspidatum) is an herb that has one of the richest known content of resveratrol, a compound that has been found in rodents to have potential anti-aging properties.
   Q. I read a number of your feedback entries on Zyflamend anti-inflammatory. When I look up Hu Zhang research shows (bummer) that it acts as estrogen and, therefore, can be contraindicated for use with people and a family history of cancer. I have a strong family background of breast, prostate, bone cancers. I like the anti-inflammatory qualities of the supplement. Now I’m bummed that I might need to stop with this “estrogen producing” portion of the supplement. I wonder why that was added when all the other ingredients in Zyflamend seem on strong research to be innocuous to anything other than inflammation?
   A. Plants have compounds that influence various receptors in the body. I have seen not evidence in humans that Hu Zhang acts as an estrogen in the body promoting cancers. Many substances in plants act as phytoestrogens, but not in the same way as the hormone. The whole topic is very complicated and one cannot accurately extrapolate the actions of the substances in these plants from lab studies into what would occur in humans if ingested. I am not concerned that the use of this plant causes or aggravates cancer formations.

Chinese Goldthread or Barberry has a unique berberine phytonutrient complex, naturally supports the inflammation response system.*

Oregano is a source of large number of compounds that promote a healthy inflammatory response.

Scutellaria: scullcap: Unique baicalin phytonutrient complex, naturally supports healthy inflammatory responses.

Animal study, benefit for oral cancer
The herbs in Zyflamend have anti oral cancer potential. A rodent study done in 2008 shows possible benefits of this supplement against oral cancer.

Zyflamend reduces LTB4 formation and prevents oral carcinogenesis in a 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced hamster cheek pouch model.
Carcinogenesis. 2008. Department of Experimental Therapeutics The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Aberrant arachidonic acid metabolism, especially altered cyclooxygenase and 5-lipoxygenase (LOX) activities, has been associated with chronic inflammation as well as carcinogenesis in human oral cavity tissues. Here, we examined the effect of Zyflamend, a product containing 10 concentrated herbal extracts, on development of 7,12-dimethylbenz[alpha]anthracene (DMBA)-induced inflammation and oral squamous cell carcinoma. Our study suggests that this herbal combination might prevent oral carcinogenesis at the post-initiation stage.

Prostate cancer
The influence of Zyflamend on prostate cancer is not fully known in humans since in order to find out for sure, Zyflamend would need to be given for at least 10 years to a group of older men and compared to another group given placebo pills. Since no such study has been done, no one knows for sure but early results look promising.

Zyflamend in men with high-grade prostatic intraepithelial neoplasia: results of a phase I clinical trial.
J Soc Integr Oncol. 2009. Department of Urology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Subjects diagnosed with high-grade prostatic intraepithelial neoplasia (HGPIN) at biopsy are at increased risk for developing prostate cancer (CaP). A prospective clinical trial was done to determine the safety and tolerability of a novel herbal amalgam, Zyflamend (New Chapter, Inc., Brattleboro, VT), with various dietary supplements in subjects with HGPIN. Men ages 40 to 75 years with HGPIN were eligible. Subjects were evaluated for 18 months. Every 3 months, standard blood chemistries and prostate-specific antigen (PSA) were monitored. Rebiopsy was done every 6 months. Tissue was evaluated for HGPIN or prostate cancer and stained for cyclooxygenase-2, nuclear factor kappaB (NF-kappaB), interleukin-6, and thromboxane. The mean PSA level was 6 ng/mL. Side effects, when present, were mild and gastrointestinal in nature. There were no reported serious adverse events or toxicities. No significant changes in blood chemistries, testosterone, or cardiac function were noted. Forty-eight percent of subjects demonstrated a 25 to 50% decrease in PSA after 18 months. Of subjects who had the 18-month biopsy, 60% (9 of 15) had benign tissue, 26% (4 of 15) had HGPIN in one core, and 13% (2 of 15) had CaP at 18 months. A reduction in serum C-reactive protein was observed. Immunoreactive staining demonstrated a reduction in NF-kappaB in the 18-month samples. Zyflamend alone and in combination with various dietary supplements is associated with minimal toxicity and no serious adverse events when administered orally for 18 months.

Nutr Cancer. 2012. Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer.

In vitro study
In the laboratory, Zyflamend decreases COX-1 and COX-2 enzyme activity. Nutrition and Cancer, 2005.
Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products. Nutrition and Cancer. 2007.

BMC Complement Altern Med. 2014. Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells.

Zyflamend side effects, safety, risk
No major serious Zyflamend side effects have been reported in the medical literature as of 2010. It is possible that certain individuals may have an allergy to one or more of the components of this product. It is always a good idea, when taking a new product, to start with the lowest dose.

Emails and testimonials
I had to stop taking Zyflamend because I determined that it causes diarrhea. It's not the turmeric, as I switched to your turmeric product without problems. My chiropractor and nutritional advisor and I have puzzled over this. Inflammation is a problem for me. It took about two weeks for us to determine that among the supplements I was taking (for h. pylori infection), something in the product was causing me to have loose stools within a few hours of taking it. After an 8 month hiatus I decided to try it again, taking one softgel, with food. I was on the toilet within an hour.
    A. This is the first report we have heard about Zyflamend side effects.

I was reviewing the information about Zyflamend on your website and wanted to write regarding the side effects I experienced. After about a month of taking it as directed, two times daily with food, I developed a severe case of diarrhea. For some time leading up to the most severe -- food in, food out w/i an hour -- I had increasingly soft stools and gurgling intestines. I didn't feel sick or anything else unusual, so I just thought it was a virus. Eventually, I went to the emergency room and none of the blood tests, urinalysis or fecal analysis indicated an infection of any sort. The ER doctor suggested I stop taking all supplements, which I did, and the diarrhea ceased in within a few days. It has been two months since then, and I decided to go ahead and try taking the Zyflamend again to see if it was the cause of the diarrhea. Unfortunately, after just a couple of days, I started experiencing loose stools and intestinal gurgling again, which will most likely lead to the diarrhea if I continue. I don't know which of the ingredients in the product cause the problem for me, but I am disappointed that I cannot take such a promising product for the inflammation in my joints.
    Interesting. This is the second report of Zyflamend side effects of diarrhea. 2008.

I just read your page and noticed two people got loose bowels from it. I have been taking it for about a month and have gotten loose bowels too. I am so disappointed because it was really helping my pain. I take it for thoracic outlet syndrome in both my arms. I could hardly get my coat on because of the pain. Some one said to take fish oil but that lowers blood pressure and I have very low blood pressure so I'm scared to take that.

I have had bouts of diarrhea with no known cause. i began to realize that it seemed to be associated with the Zyflamend. i did several trials of not taking it and taking it. it became obvious that it was the supplement.

Q. My dad was a doctor and very good homeopath too so I have been against drugs in principal. I got breast cancer however, and after surgery, 2 months radiation, and 5 years of Letrozole, an AI, I got osteopenia. Right after I fell 9 feet breaking clavicle and ribs which healed crookedly. My spine is not great, and my hips have little or no cartilage. So I think I must have one hip operated on, at least. In 2012 the groin and hip pains etc were helped first by Advil, and then much better, by Zyflamend or Bromelain. I read that anti-inflammatory drugs prevent bone from forming. Has there been any research to show that a similar effect happens when anti-inflammatory herbs Like Zyflamend are used? It recently occurred to me that by constantly taking Zyflamend, I may be making my now reduced hip cartilage even less, or worse!
   A. I am not aware of any research that the use of the herbs found in this natural product can have a negative effect on bone formation.

Withdrawal symptoms?
I have been taking,1 tablet once a day, of New Chapter Zyflamend for the last 5 years. Money has gotten tight, so I quit taking it. About 2 days after I stopped I have been having extreme gas pains in my abdomen. It's like a large bubble, that I can't burp up. I have been having, a whole lot of acid, that also causes pain in my abdomen. Every night for the last 5 days, I have been taking Gasx and Rantitidine 75mg and 150mg. I also take baking soda. It gets really bad at night. My diet is pretty well-rounded. meat, vegetables and fruit I cook in, no fast food. I haven't taken anything or eaten anything that is different. Tonight, my blood pressure went way up. 192/149. My blood pressure is now back down, but my abdomen is still in pain. I am not sure if these are withdrawal symptoms.
   A. It is difficult to say. I do not have any patients who have taken it with such regularity for so long and then stopped abruptly.

Interactions with medications
Q. My husband is taking warfarin. Is it advisable to take Zyflamend if he is on Coumadin?
   A. I have not seen studies regarding the blood thinning properties of this herbal formula, but some of the ingredients can cause blood thinning and therefore one has to be cautious about their use together.

New Chapter Zyflamend research study results
Zyflamend, a Polyherbal Preparation, Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis Through Down-Regulation of NF-kappa B Activation and NF-kappa B-Regulated Gene Products.
Nutr Cancer. 2007. Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas.
Zyflamend, a polyherbal preparation, was designed based on constituents that exhibit antiproliferative, antiinflammatory, antioxidant, antiangiogenic, and apoptotic activities through a mechanism that is not well defined. Because the nuclear factor (NF)-kappaB has been shown to regulate proliferation, invasion, and metastasis of tumor cells, we postulated that this herbal formula modulates the activity of NF-kappa B. To test this hypothesis, we examined the effect of this preparation on NF-kappaB and NF-kappaB-regulated gene products. We found that Zyflamend inhibited receptor activator of NF-kappa B ligand-induced osteoclastogenesis, suppressed tumor necrosis factor (TNF)-induced invasion, and potentiated the cytotoxicity induced by TNF and chemotherapeutic agents, all of which are known to require NF-kappa B activation. Overall, our results indicate that Zyflamend suppresses osteoclastogenesis, inhibits invasion, and potentiates cytotoxicity through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.

Zyflamend, a unique herbal preparation with nonselective COX inhibitory activity, induces apoptosis of prostate cancer cells that lack COX-2 expression.
Nutr Cancer. 2005. Department of Urology, Columbia University Medical Center, New York, NY
Zyflamend inhibited both COX-1 and COX-2 enzymatic activities, suppressed cell growth, and induced apoptosis in LNCaP cells.

Testimonials by email
I have arthritis and nerve pain and it does help.

Q. I read that Zyflamend is a Cox inhibitor. Is that true?
   A. One laboratory study has shown that the herbs in Zyflamend inhibited both COX-1 and COX-2 enzymatic activities, suppressed cell growth, and induced apoptosis in prostate cancer cells. Whether these same benefits would occur if humans ingested this supplement for prolonged periods is not known at this time.

Q. Am considering taking either serrapeptase or Zyflamend for inflammation reduction and prostate wellbeing. Do you have any comparative research analyzing these two herbal products? Serrapetase and Zyflamend both seem fairly similar in their performance.
   A. There is very little human research regarding either one, and we have not come across any evaluative studies comparing the two.

Q. I am currently breastfeeding and am wondering if any info is available on the safety of taking Zyflamend 120 while nursing.
   A. Many of the herbs in Zyflamend are healthy herbs that are normally found in the kitchen, however we have not seen any specific research with the use of Zyflamend and breastfeeding. We have no reason to suspect any untoward reaction would occur but we can't be 100 percent sure.

Q. I understand it is being promoted, what inflammatory conditions would it be useful for? I am a naturopathic doctor and would like to use New Chapter Zyflamend for certain patients who may benefit from this product.
   A. It is quite likely that Zyflamend may be of benefit in certain medical conditions due to a wonderful mix of natural herbs it contains, however such human research is not available for us to make any definitive statements at this time.

Q. Would Zyflamend be detrimental to someone with cirrhosis?
   A. We have not seen any studies in regards to cirrhosis or liver enzymes.

I am the medical director of an integrative healing center at a major university. I wanted to let you know about a study. Here is the press release from 2005. "Data from the Columbia University Department of Urology demonstrates that Zyflamend, a unique herbal extract preparation, suppresses the growth of prostate cancer cells and induces prostate cancer cells to self-destruct via a process called “apoptosis.” The data, published in the October edition of Nutrition and Cancer, showed Zyflamend, a patented formulation from New Chapter, has the ability, in vitro, to reduce prostate cancer cell proliferation by as much as 78 percent and to induce cancer cell death or apoptosis. The research confirms Zyflamend has COX-1 and COX-2 anti-inflammatory effects, although its anti-cancer effects against prostate cancer were independent of COX-2 inhibition, supporting the postulation that some prostate cancer cells are not affected by COX-2 inflammation. Based on this research, Zyflamend shows value in early therapy for prostate cancer patients. On the strength of this laboratory research, Columbia University’s Department of Urology has commenced a Phase 1 human clinical trial testing Zyflamend ability to prevent prostate cancer in patients with prostatic intraepithelial neoplasia (PIN)."

While there are benefits to inhibiting cox enzymes, these same enzymes perform important functions in the body. In the kidneys they produce prostaglandins like pge 2 that maintain renal hemodynamcis. NSAIDS are toxic to kidneys because they interfere with these same prostaglandins. Is Zyflamend safe for the kidneys? It is interesting to note that people also suffer from ulcers from NSAID use, but don't seem to with Zyflamend.
   Not enough human research has been done with Zyflamend to determine its long term benefits and side effects. There are many herbs in Zyflamend and each herb has many compounds which all work in different ways rather that strictly as COX-2 inhibiting enzymes. Therefore, the effects of the herbs in Zyflamend supplements are not the same as taking a medication that is purely a COX-2 inhibitor.

My husband has costochondritis and his doctor recommended him to take glucosamine with chondroitin for 3 months then stop the treatment for a month and then start it for another 3 months until 1 year, he already took it for the first 3 months, the pain comes and goes several time per week. I read about Zyflamend in a magazine, do you think that it can work for my husband? I'm really stress about this thing because of the place of the pain, we been several times in the emergency room of the Hospital thinking that it my be his heart and after been with a cardiologist, a gastroenterologist, even a pediatrician! and after all the test and studies you can imagine, they all end in that conclusion.
   It is impossible for us to predict whether Zyflamend will help with your husband but we wish him well. We have not come across any human research with the use of Zyflamend for costochondritis as of August 2008.

I noticed a reader asked you a question about taking resveratrol with Zyflamend, I would just like to point out that according to newchapter.com's website that Zyflamend contains Hu Zhang (Polygonum cuspidatum) (root and rhizome) yielding 6.4mg of resveratrol in its formula, so my guess is that taking resveratrol with Zyflamend wouldn't hurt (but then again I'm not a doctor).
    The amount of resveratrol in this formula is not high compared to a capsule of resveratrol sold by itself. I don't know what the long term effects would be if both are combined on a daily basis.

I recently came upon Zyflamend. It seemed to be a wonderful medicine for inflammation for my aches and pains but before I took it, I did some research on it because I have the Long QT syndrome and many medicine and even supplements have the potential to prolong the QT interval. Could you tell me if berberine is beneficial or on the contrary would have an adverse effect on the heart, prolonging the QT interval?
    I have not seen such studies, plus the amount of berberine in this product is not too high. Some of the other herbs in the product, or the combination, may have an influence on heart rhythm but little research is available to know much in detail.

I am a 61 y/o white female with some general inflammation, and specifically in certain joints (bone spurs in both knees). It has become increasingly difficult for me to walk without pain. I was recently advised by someone in a health food store to take an herbal supplement called Zyflamend. After some online research, I discovered that there may be some contraindications for people taking certain prescription medications but could not find any specific reference as to which medications were involved. I currently take Lisiniprol for high blood pressure and Zetia for slightly elevated cholesterol (I was unable to continue taking any of the more common cholesterol-lowing medications because of my adverse reactions to them, e.g . pain in the extremities). Is there any contraindications to my taking this herbal formula with these prescription drugs?
   I have not seen any studies that have evaluated the combinations therefore it is not easy to know how any one person will respond to mixing them.