Wrinkle reduction, natural products, supplements by Ray Sahelian, M.D.
December 15 2016

Wrinkles are a natural result of the skin's loss of elasticity as it ages. Some behaviors can speed up the process and cause wrinkles prematurely. To reduce wrinkles around your eyes, sleep on you back rather than on your belly. Coarse facial wrinkles, brown or pink spots, and dilated blood vessels are caused by too much time in the sun, smoking, and being overweight.

To reduce the risk for wrinkles, follow these suggestions:
Avoid prolonged, direct exposure to sunlight. If you do have to be out in the sun, protect your skin with a hat and plenty of sunscreen. Get a pair of good sunglasses, which can protect skin around the eyes from sun damage and keep you from squinting.
Don't use tanning beds.
To reduce lines around the eyes, sleep on your back rather than on your side since sleeping on your side places your face on the pillow and tends to push your cheeks toward your eyes causing lines to deepen. Sleeping on your side increases wrinkles on cheeks and chin, while sleeping facedown gives you a furrowed brow.
Don't smoke or reduce the number of cigarettes you smoke..
Keep your skin well-moistened with creams and lotions.

Diet and food, what to eat
Salmon and other cold-water fish a great source of essential fatty acids known as omega-3s. These essential fatty acids nourish skin and keep it plump and youthful, helping to reduce wrinkles. Fish also are a great source of protein. Fish oil, krill oil, and flax seed oil are other options. If you live caviar, or salmon roe, then you are in luck since these fish eggs have the wonderful fatty acids EPA and DHA that are excellent for skin health.

Supplements for wrinkle improvement
Skin health
Clin Interv Aging. 2015. The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity. o evaluate the effects of a rose hip powder (Hyben Vital()) made from seeds and shells on cell senescence, skin wrinkling, and aging. A total of 34 healthy subjects, aged 35-65 years, with wrinkles on the face (crow's-feet) were subjected to a randomized and double-blinded clinical study of the effects of the rose hip powder, as compared to astaxanthin, a well-known remedy against wrinkles. During the 8-week study, half of the participants ingested the standardized rose hip product, while the other half ingested astaxanthin. Objective measurements of facial wrinkles, skin moisture, and elasticity were made by using Visioscan, Corneometer, and Cutometer at the beginning of the study, after 4 weeks, and after 8 weeks. Evaluation of participant satisfaction of both supplements was assessed using questionnaires. In addition, the effect of the rose hip preparation on cell longevity was measured in terms of leakage of hemoglobin through red cell membranes (hemolytic index) in blood samples kept in a blood bank for 5 weeks. The rose hip group showed statistically significant improvements in crow's-feet wrinkles, skin moisture, and elasticity after 8 weeks of treatment. A similar improvement was observed for astaxanthin. Likewise, both groups expressed equal satisfaction with the results obtained in their self-assessment. The rose hip powder further resulted in increased cell longevity of erythrocyte cells during storage for 5 weeks in a blood bank. Results suggest that intake of the standardized rose hip powder Hyben Vital improves aging-induced skin conditions. The apparent stabilizing effects of the rose hip product on cell membranes of stored erythrocyte cells observed in this study may contribute to improve the cell longevity and obstructing skin aging.

Avoid squinting
Repetitive facial movement -- like squinting -- overworks facial muscles, forming a groove beneath the skin's surface. This groove eventually becomes a wrinkle. Wear reading glasses if you need them.

Retinoic acid wrinkle cream
In my opinion the prescription medication based anti wrinkle cream retinoic acid is quite effective and can be used every other day for many years.

Wrinkle cream products - do they work?
Alpha-hydroxy acids are natural fruit acids that pee; away the top layer of dead skin cells, reducing the appearance of fine lines and wrinkles, particularly around the eyes. In higher concentrations, AHAs may help stimulate collagen production.

Topical vitamin C, L ascorbic acid, may be of benefit in increasing collagen production.

A topical antioxidant complex containing vitamins C and E and ferulic acid has potential photoprotective effects against solar-simulated ultraviolet irradiation-induced acute photodamage in human skin.

Luxury-price anti wrinkle products don't work any better than drugstore brands, according to the study by Consumer Reports magazine, which ranked Olay Regenerist, priced at about $19, as the most effective in reducing wrinkles. But none of these products made a significant difference in the skin's appearance. After 12 weeks the top-rated anti wrikle products smoothed out some fine lines and wrinkles, but even the best performers reduced the average depth of wrinkles by less than 10 percent, a change barely visible to the naked eye. Consumer Reports, published by nonprofit consumer research group Consumer Union, chose a sample of top-selling mass-market lines for its study. The products were purchased in retail stores for between $19 and $355. Each anti wrinkle cream was tested by 17 to 23 women, aged between 30 and 70. The women used a test product on one side of their face and the lab's standard moisturizer on the other side for comparison.

Is a wrinkle cream a cosmetic or a drug?
A wrinkle cream is still a cosmetic unless a claim is made that the mechanism for wrinkle lessening is physiological. In other words, creams that moisten the skin and cover wrinkles are cosmetics and not drugs. Botox, which has a physiological reaction within the body, is a drug used for cosmetic purposes.

Botox danger for wrinkles
2008 - Botox and a similar injection for wrinkle treatment have caused 16 deaths and other serious problems after the botulinum toxin spread inside the body. Public Citizen asked U.S. authorities to require the strongest possible warning, highlighted in a "black box," on Allergan Inc's Botox and Solstice Neuroscience Inc's Myobloc.

Wrinkles around eyes, cause
Facial wrinkles -- such as so-called "laugh lines" or "crow's feet" are more common due to differences in oil-secreting glands just below. Forehead wrinkles are shallower than wrinkles around the outer eye. Sebaceous glands are "microscopic glands that secrete sebum, an oily or waxy material, which lubricates the skin and protects it from water damage. Wrinkles in the face tend to be deeper where sebaceous glands are less concentrated -- namely, the outer corners of the eyes.