Schizandra herb health benefit by Ray Sahelian, M.D.
January 10 2017

Extracts from the fruits (seeds) of Schizandra chinensis are one of the components of medicinal preparations designed for the treatment of cardiovascular diseases, liver diseases, diseases of the central nervous system related to the old age, as a supplement in the treatment of neoplasms, diabetes, etc. Schizandra extracts are also used for the production of nutraceuticals (soft drinks and health foods), preparations for oral hygiene and for the care for the skin and hair.

Paradise Herbs
buy Schizandra Extract, 250 mg
Schizandra is naturally extracted using only the finest quality Fructus Schizandra chinesis. Our standardized extract provides active levels of schisandrins, concentrated in the balanced ratio nature intended, without isolating, fractionizing or using toxic solvents, harsh chemicals or gases.
Schizandra is a famous tonic traditionally used by both royalty and master herbalists. It is one of the few herbs that contain the three treasures known as Jing, Qi and Shen. Traditionally used for enhancing the energy of the kidney and liver, It is known for supporting memory and sexual health. It is mildly calming and helps strengthen the primary energies of life.*

Buy Schizandra supplement

Supplement Facts Schizandra Fruit extract
Serving Size: 1 Vegetarian Capsule
  Amount Per Vegetarian Capsule % Daily Value
Schizandra chinensis fruit extract 10:1
Wu Wei Zi
250 mg *
*Daily Value not established.

Suggested Use: 1 capsule daily or as directed by a qualified healthcare professional

Supplement Facts: Amount Per Serving
Schizandra chinesis fruit 10:1 - 250 mg
   with Schisandrins

Other products to buy online
Nature's Way, Schizandra Fruit, 580 mg, 100 Capsules

Other popular herbs and products are
Ashwagandha, Bacopa, Fo-Ti, Ginkgo biloba, Ginseng, Mucuna pruriens, Rhodiola, and Reishi, along with, Carnitine, Carnosine, Choline, DMAE, Inositol, Methylcobalamin, Pantothenic acid, Trimethylglycine, Tyrosine, and Vinpocetine.  

Benefit of Schizandra berry
Schizandra chinensis, originally a Japanese-Manchurian endemite, yields a vegetable drug (Schizandrae fructus) with a number of very utilizable therapeutic effects. Studies indicate schizandra has hepatoprotective, adaptogenic, and antioxidative capabilities. It is obvious that a very positive therapeutic effect based on the use of a complex mixture of schizandra's principal constituents because their biological effects are complementary and potentiate each other. At the same time, some lignans (e.g. gomisin A, gomisin N) are interesting as new prospective medicines. For a list of herbs used in Chinese medicine, see Chinese Herbs.

Components of Schizandra
Some of the active ingredients in schizandra include
dibenzocyclooctadiene lignans, schizandrin, wuweizisu A, B, C;wuweizichun A, B; wuweizi ester and schisanhenol.
Essential oils of Schisandra chinensis seeds and berries without seeds were separately extracted. A total of 55 compounds were identified including α-cis-bergamotene, selinadiene, α-cadinol, ylangene, β-himachalene and di-epi-α-cedrene.

Antioxidant and liver protection
Previous studies in our laboratory have demonstrated the effect of Schizandrin B (Sch B), an active ingredient of the fruit of Schizandra chinensis, on enhancing the hepatic glutathione antioxidant system in mice, as evidenced by the hepatoprotection against carbon tetrachloride (CCl4) toxicity. Our results strongly suggest that the mechanism of hepatoprotection afforded by Sch B treatment may involve the enhancement of mitochondrial glutathione redox status.

Protection of brain cells
Dibenzocyclooctadiene lignans from Schizandra chinensis may possess therapeutic potential against oxidative neuronal damage induced by excitotoxins.

Food Chem Toxicol. 2013. Antitumor and immunomodulatory activity of a water-soluble low molecular weight polysaccharide from Schisandra chinensis.

Pharm Biol. 2015. Schizandra chinensis extracts induce apoptosis in human gastric cancer cells via JNK/p38 MAPK activation and the ROS-mediated/mitochondria-dependent pathway. Schizandra chinensis fruit extract  is considered a traditional herbal medicine for the treatment and alleviation of various diseases. Gastric cancer is the second most common cause of cancer-related death worldwide, and the first most common in Korea. Results indicate that it might be an effective chemotherapeutic for the treatment of human gastric cancer.

Heart disease
Fitoterapia. 2014. The protective effects of Schizandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Schizandra chinensis fruit extract has traditionally been used as an oriental medicine for the treatment of various human diseases, including cardiovascular disease. To date, emerging experimental evidence supports the therapeutic effects of the Schizandra or its bioactive lignan ingredients in cardiovascular disease, unraveling the mechanistic basis for their pharmacological actions.

J Tradit Chin Med. 2012. Inhibition mechanism of compound ethanol extracts from wuweizi (fructus schisandrae chinensis) on renal interstitial fibrosis in diabetic nephropathy model mice.

Schizandra Research papers
Extracts from Schizandra chinensis fruit activate estrogen receptors: a possible clue to its effects on nitric oxide -mediated vasorelaxation.
Biol Pharm Bull. 2004.
Schizandra chinensis fruit has long been used for the treatment of cardiovascular symptoms associated especially with menopausal symptoms in Korea. To provide a scientific rationale for such uses, we have investigated the vasorelaxant effects of Schizandra chinensis fruit on the vasomotor tone of the rat thoracic aorta in an organ bath. The crude extracts of the fruit elicited a transient relaxing response in the endothelium-intact rat aorta contracted with norepinephrine. This relaxant effect was abolished by removal of the endothelium, and also by pretreatment with nitric oxide synthase inhibitor. We then examined whether this vasodilatory effect occurs through estrogen receptor by reporter assays. Schizandra chinensis activated the estrogen-responsive luciferase gene in COS cells transiently transfected with estrogen receptor and reporter plasmids. Reporter gene activation by Schizandra chinensis-ADF was inhibited by the specific estrogen receptor antagonist ICI 182,780, indicating that the effect is estrogen receptor dependent. However, Schizandra chinensis-ADF failed to activate the androgen receptor in COS cells transfected with the corresponding receptor and reporter plasmids. Our data show that extracts of Schizandra chinensis fruit act as a weak phytoestrogen.

What does it mean that schizandra berry activates estrogen receptors? Does that have anything to do with breast cancer?
   Phytoestrogens have protective effects against breast cancer.

Double-blind, placebo-controlled, randomized, pilot clinical trial of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees, with Eleutherococcus senticosus Maxim, Schizandra chinensis and Glycyrrhiza glabra extracts in patients with Familial Mediterranean Fever.
Republican Children's FMF Center, Yerevan State Medical University, Yerevan, Armenia.
Phytomedicine. 2003.
Double blind, randomized, placebo controlled pilot study of ImmunoGuard--a standardized fixed combination of Andrographis paniculata Nees., Eleutherococcus senticosus Maxim., Schizandra chinensis Bail., and Glycyrrhiza glabra special extracts standardized for the content of Andrographolide (4 mg/tablet), Both the clinical and laboratory results of the present phase II (pilot) clinical study suggest that ImmunoGuard is a safe and efficacious herbal drug for the management of patients with FMF.

Liquid chromatographic analysis of supercritical carbon dioxide extracts of Schizandra chinensis.
J Chromatogr B Analyt Technol Biomed Life Sci. 2002.
Six major lignans (schizandrin, gomisin A, deoxyschizandrin, y-schizandrin, gomisin N, wuweizisu C) in the caulomas and leaves of Schizandra chinensis, and cinnamic acid in the leaves of the plant, were quantitatively analysed by high-performance liquid chromatography in reversed-phase mode with UV detection.