Royal Jelly benefit, side effects, research information of this health supplement by Ray Sahelian, M.D.
November 1 2016

Royal jelly, which is secreted from the salivary glands of worker bees, serves as food for all young larvae and as the only food for larvae that will develop into queen bees. It contains a mix of vitamins, minerals, proteins and fatty acids, along with acid glycosides and sterols, such as stigmasterol. Half of the dry weight of royal jelly is made of protein. Studies in rodents indicate royal jelly has anti-inflammatory and anti-tumor properties. See also bee pollen and propolis.

Health benefit of royal jelly -- anti-aging properties?
A study in mice showed royal jelly given for 16 weeks helped them live longer. Whether royal jelly has longevity benefits in humans is not known. Rodent studies also indicate that royal jelly has beneficial effects on bone strength.

Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage.
Exp Gerontol. 2003.
The effect of dietary royal jelly was tested on tissue DNA oxidative damage and on the life span of C3H/HeJ mice that were fed the dietary supplement for 16 weeks. Our results indicated that dietary royal jelly increased the average life span of C3H/HeJ mice, possibly through the mechanism of reduced oxidative damage.

Royal jelly and blood pressure
Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats.
Acta Med Okayama. 2009. Department of Research and Development, Yamada Apiculture Center, Inc., Kagamino, Okayama, Japan.
Angiotensin I-converting enzyme (ACE) inhibitory and hypotensive effects of 7 peptide fractions of royal jelly protein hydrolysate were studied in comparison with those of royal jelly protein hydrolysate alone. Our results show that the long-lasting hypotensive effect of oral administration of protein hydrolysate is dependent on the molecular weight of its ACE inhibitory peptides and the time required to digest them.

Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats.
Biol Pharm Bull. 2004.

Could you please confirm my understanding that toyal Jelly has not contraindications with regards to patients taking high blood pressure medication and that it could improve the condition.
   I have not seen human studies yet, so I am not confirm that it would lower blood pressure or not interact with medications.

A study in humans reveals royal jelly supplements lower cholesterol levels.

Royal jelly supplementation improves lipoprotein metabolism in humans.
J Nutr Sci Vitaminol. 2007. R&D Center, Nippon Meat Packers, Inc.
The researchers examined the effects of royal jelly supplements on cholesterol and triglycerides. A few volunteers took 6 g a day of a royal jelly supplement for 4 weeks. Their serum total cholesterol and serum low-density lipoprotein (LDL) decreased significantly compared with those of the control group. There were no significant differences in serum high-density lipoprotein (HDL) or triglyceride concentrations.

Fatigue and energy, endurance
Anti-fatigue effect of fresh royal jelly in mice.
J Nutr Sci Vitaminol 2001.
We investigated the anti-fatigue effect of royal jelly, which had been stored at -20 degrees C from immediately after collection, in male Std ddY mice. Mice were separated into three groups with equal swimming capacity, and were administered royal jelly, royal jelly stored at 40 degrees C for 7 d (40-7d royal jelly), or the control solution including casein, cornstarch, and soybean oil before swimming. All mice were forced to swim for 15 min once; then the maximum swimming time to
fatigue was measured after a rest period. The swimming endurance of the royal jelly group significantly increased compared with those of the other groups. The mice in the royal jelly group showed significantly decreased accumulation of serum lactate and serum ammonia and decreased depletion of muscle glycogen after swimming compared with the other groups, whereas there was no significant difference between the 40-7d RJ group and the control group in these parameters after swimming. A quantitative analysis of constituents in royal jelly showed that 5 7-kDa protein, which we previously identified as a possible freshness marker of royal jelly, was specifically degraded in royal jelly stored at 40 degrees C for 7 d, whereas the contents of various vitamins, 10-hydroxy-2-decenoic acid, and other fatty acids in RJ were unchanged. These findings suggest that royal jelly can ameliorate the physical fatigue after exercise, and this anti-fatigue effect of royal jelly in mice seems to be associated with the freshness of RJ, possibly with the content of 5 7-kDa protein.

Premenstrual syndrome
Complement Ther Med. 2014. Effect of Royal Jelly on premenstrual syndrome among Iranian medical sciences students: a randomized, triple-blind, placebo-controlled study. Premenstrual syndrome (PMS) may have negative effects on women's health and sometimes need therapeutic non-pharmacological management. :To determine the effect of oral consumption of 1000 mg Royal Jelly capsule on premenstrual syndrome. This is a randomized, triple-blind, placebo-controlled clinical trial, which was conducted in Tehran University of Medical Sciences female dormitories between December 2011 and October 2012. The study population comprised 110 medical sciences student with PMS, whom were randomly assigned to an intervention or a control group. Each participant in the intervention group took one Royal jelly capsule orally per day, starting on the first day of menstruation and continued the same treatment daily throughout two consecutive menstrual cycles, while participants in the intervention group took placebo capsules as same method. The outcome measure in this study was PMS score as obtained through the Premenstrual Profile 2005. The results of the study have demonstrated that 2 months consumption of Royal Jelly was effective in reducing PMS.

Royal Jelly side effects and caution
A very small number of individuals may have allergic reactions to royal jelly.
Asthma, together with, in some rare cases, anaphylaxis, has been observed in subjects following ingestion of royal jelly. Perhaps royal jelly has blood thinning potential and hence those on warfarin ( Coumadin ) should be cautious.

Food-induced anaphylaxis caused by ingestion of royal jelly.
J Dermatol. 2006. Division of Dermatology, Machida Municipal Hospital, Tokyo, Japan.
We report a case of food-induced anaphylaxis caused by ingestion of royal jelly. After taking royal jelly and several other medicinal products, a 33-year-old Japanese male developed severe facial pruritus and erythema, followed by vertigo, numbness in his fingers, generalized pruritus, wheals, dyspnea, wheezing and impaired consciousness. He was treated with corticosteroid and fluid therapy, and his symptoms subsided. Upon allergy testing, his only positive reaction was to royal jelly. Given the clinical symptoms and the positive prick test to royal jelly, a diagnosis of anaphylaxis due to the ingestion of royal jelly was made.

Royal jelly is sold in various ways, including fresh royal jelly, pure, honey, capsule  and combined with other nutrients or herbs such as ginseng. Organic royal jelly is preferable.

Summary and review
There are few human trials with royal jelly, therefore, it is difficult to say what long term benefit royal jelly would have if consumed daily. The ideal royal jelly dosage in humans is also unknown. It appears that taking a royal jelly supplement a few times a week or month would have health benefits.

What kinds of tests are done to unsure a royal jelly products meets specifications?
   The product is tested for 10-Hydroxy-2-Decenoic Acid (10-HAD), one of the specific unsaturated fatty acids found in royal jelly. 10-HDA is a substance that young bees produce in their mandibular glands, and is known as an important active ingredient to fight bacteria, viruses and fungus.

Royal Jelly studies
Environ Toxicol Pharmacol. December 2013. Royal jelly attenuates azathioprine induced toxicity in rats.

Syst Biol Reprod Med. December 2013. Royal jelly protects from taxol-induced testicular damages via improvement of antioxidant status and up-regulation of E2f1.

Royal jelly inhibits the production of proinflammatory cytokines by activated macrophages.
Biosci Biotechnol Biochem. 2004.
When supernatants of RJ suspensions were added to a culture of mouse peritoneal macrophages stimulated with lipopolysaccharide and IFN-gamma, the production of proinflammatory cytokines, such as TNF-alpha, IL-6, and IL-1, was efficiently inhibited in a dose-dependent manner without having cytotoxic effects on macrophages. This suggests that RJ contains factor(s) responsible for the suppression of proinflammatory cytokine secretion. We named the factor for honeybees RJ-derived anti-inflammatory factor (HBRJ-AIF), and further investigated the molecular aspects of it. Size fractionation study showed that HBRJ-AIF is composed of substances of low (< 5 kDa) and high (> 30 kDa) molecular weights, with the former being a major component. Chromatographic analysis showed that MRJP3 is one candidate for the HBRJ-AIF with high molecular weights. Thus, our results suggest that RJ has anti-inflammatory actions through inhibiting proinflammatory cytokine production by activated macrophages.

Case report: haemorrhagic colitis associated with royal jelly intake.
J Gastroenterol Hepatol. 1997.
The case report of a 53-year-old woman with abdominal pain and bloody diarrhoea is described. Prior to the onset of symptoms the patient had taken royal jelly for 25 days. Colonoscopy revealed that the mucosa was haemorrhagic and oedematous throughout the 20 cm long sigmoid colon. Histopathologically, mucosal haemorrhage, oedema, and infiltration of inflammatory cells were observed. Transmission electron microscopic examination revealed platelet aggregation in 30% of capillaries in the mucosal lesions. The drug-induced lymphocyte stimulation test was slightly positive for royal jelly (847 c.p.m., SI = 147%) compared with the control (576 c.p.m.). The patient's signs and symptoms disappeared within a few days after the initiation of conservative therapy, and the colonic lesions disappeared after 2 weeks of this therapy. This is the first reported case of haemorrhagic colitis associated with royal jelly intake.

Royal jelly consumption and hypersensitivity in the community.
Clin Exp Allergy. 1997.
Royal jelly consumption has recently been linked with acute asthma, anaphylaxis and death. A cross-sectional survey was conducted to determine the prevalence of and the relationship between royal jelly consumption and hypersensitivity reactions. 1472 hospital employees of a teaching hospital in Hong Kong completed a questionnaire on royal jelly consumption and related allergic symptoms, and 176 questionnaire respondents and 300 consecutive asthma clinic patients were skin tested to royal jelly. Royal jelly consumption was high, with 461 out of 1472 subjects (31.3%) having taken royal jelly in the past. A total of nine subjects reported 14 adverse reactions to royal jelly, including urticaria, eczema, rhinitis and acute asthma. Thirteen out of 176 questionnaire respondents (7.4%) and 23 out of 300 consecutive asthma clinic attendees (7.3%) had positive skin test to pure royal jelly. All but one of the 36 subjects with positive royal jelly skin test were atopic to other common allergens. Positive associations were found between positive royal jelly skin test and atopy adverse reactions to royal jelly and a history of clinical allergy, but not between royal jelly symptoms and previous royal jelly intake. Royal jelly consumption is high in the community of Hong Kong. Atopic individuals are at high risk of sensitization to royal jelly but the precise relationship between royal jelly use, positive royal jelly skin test and clinical manifestations of adverse reactions to royal jelly, remains to be defined.

Asthma and anaphylaxis induced by royal jelly.
Clin Exp Allergy. 1996.
Asthma, together with, in some cases, anaphylaxis, was observed in seven subjects following ingestion of royal jelly, a secretion of honey bees which is used as a health tonic. To determine if reactions were IgE-mediated and to identify allergenic components of royal jelly. Skin-prick tests, immunoassays for specific IgE antibodies and protein blotting studies using patients' sera and anti-IgE second antibodies were employed. Immunoassays detected IgE antibodies to royal jelly proteins in sera of subjects who reacted to the substance. A total of 18 different IgE-binding components were detected on blots following electrophoretic separation of royal jelly under dissociating conditions. Examination of 63 sera from subjects allergic to bee venom showed that there is no direct relationship between IgE antibody reactivity to bee venom allergens and to royal jelly proteins although 38% of the sera reacted with a royal jelly solid phase. IgE antibody reactivity to royal jelly proteins was also detected in 52% of 75 subjects with allergies to inhalant and/or food allergens. Antibody binding of blotted royal jelly proteins was most marked in the molecular weight region 25-55 kDa and one component of MW approximately 55 kDa was detected by all of the reactive sera from royal jelly-allergic and control allergic subjects. Symptoms of asthma and anaphylaxis seen in subjects following ingestion of royal jelly were true IgE-mediated hypersensitivity reactions. The clinical significance of the antibodies found in the sera of control subjects is not known but they may arise in response to common inhalant allergens that show allergenic cross-reactivity with royal jelly.

I have a Bee Pollen question that I need some feedback regarding. I now take a teaspoon of high quality royal jelly and I would like to know if it would be ok to start taking about a teaspoon a day of Bee Pollen along with the royal jelly? The royal jelly works fine but I wanted the added benefits of the bee pollen as well. Is there a superior brand of Bee Pollen?
   Each person has a unique biochemistry and it is impossible to predict whether you would benefit from adding bee pollen.

I would like to ask about Royal Jelly, I'm 19 years old, is it good to consume 2000mg in the morning or better not consume it? What's the best dosage for me(19/male)?
   This is a healthy supplement to use a couple of times a week by most people. I can't give specific dosage guidance since each person is different in how they respond.

I contact you because I would like to share an experience with you. What I discovered is that if I take ginko biloba, royal jelly and kurkuma on the same time it has an incredible potency enhancing effect. I checked on the internet and I didnít see anywhere such natural potency enhancer which would be composed by gingo biloba + royal jelly + kurkuma (curcumin, turmeric). I believe that if you would have such a new product it would be a great success.

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Supplement Facts
Serving Size: 2 Softgels
Servings Per Container: 50
  Amount Per Serving % Daily Value
Royal Jelly (min. 6% 10-HDA)(a 3.3:1 freeze-dried concentrate equivalent to 600 mg of fresh Royal Jelly) 182 mg *
*Daily Value not established

Suggested Use: 1 to 2 royal jelly capsules daily, or as recommended by your health care professional.

Royal Jelly is a milk like secretion made by worker bees in the hive. It is so named because it serves as the sole food for the queen bee. It supplies all the B-vitamins, vitamins A, C, D, E and K, more than a dozen key minerals. 18 amino acids, and other important constituents, including nucleic acids (DNA and RNA). Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) are also found in Royal Jelly.

Caution: Bee products may cause an allergic reaction in some people. Discontinue use if this occurs. If you are pregnant or breast feeding, consult your health care professional before using this product.

Other products contain
Supplement Facts: Freeze-Dried Royal Jelly - 167 mg (equivalent to 500 mg fresh Royal jelly)
Now Foods, Royal Jelly, 10 oz (284 g)
Buy Royal Jelly supplement. Also consider Bee Pollen supplement and Propolis pills.