Punicalagin in pomegranate fruit and juice
February 1 2017

Punicalagins are large polyphenol compounds and are found in forms alpha and beta in pomegranates. They strongly contribute to pomegranate juice's antioxidant properties.

Glioma tumor
Acta Pharmacol Sin. 2013. Punicalagin induces apoptotic and autophagic cell death in human U87MG glioma cells.

Herpes simplex infection
We report that chebulagic acid and punicalagin, two hydrolyzable tannins isolated from the dried fruits of Terminalia chebula, inhibit HSV-1 entry at noncytotoxic doses in A549 human lung cells. We suggest that the hydrolyzable tannins chebulagic acid and punicalagin may be useful as competitors for glycosaminoglycans in the management of HSV-1 infections and that they may help reduce the risk for development of viral drug resistance during therapy with nucleoside analogues. J Virol. 2011. Hydrolyzable tannins (chebulagic acid and punicalagin) target viral glycoprotein-glycosaminoglycan interactions to inhibit herpes simplex virus 1 entry and cell-to-cell spread.. Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada.

Pregnancy, potential benefit
Biochemical and Biophysical Research Communications. 2015. Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects.

A lot of sources refer to the benefits of punicalagin acid, not ellagic acid. But I also read that punicalagin acid will turn into ellagic acidÖ I am a bit confused whether one can get more benefits by using the pomegranate extract thatís standardized to punicalagin acid, or one thatís standardized to ellagic acid. I would appreciate your comments in general about taking punicalagin acid vs. taking in ellagic acid in human body.
   There are not enough long term human studies to determine which is best. Sometimes we get bogged down in minutiae and miss the forest for the trees. One should rather focus on obtaining a wide variety of antioxidants from various sources rather than focusing too much on these types of details.