Pheromones information
June 20 2018
by Ray Sahelian, M.D.

Pheromones are naturally occurring substances the fertile body excretes externally, conveying an airborne message to trigger a sexual response from a member of the same species. Pheromones and other semiochemicals play an important role in the natural world by influencing the behavior of plants, mammals, and insects. In the latter case, species-dependent pheromone communication has numerous applications, including the detection, trapping, monitoring and guiding of insects, as well as pest management in agriculture.

A mystery chemical isolated from the sweat of young women seems to act as a romance booster for their older counterparts. When the researchers added the compound, Pheromone 10:13, to a perfume and gave it to older women, it made their partners more affectionate. In diaries kept by the women for 6 weeks, 41 percent of pheromone users reported more petting, kissing and affection with partners. Pheromones are airborne chemicals secreted from the body and recognized by their smell. Humans and animals emit pheromones. Joan Friebely of Harvard University and Susan Rako, a doctor from Newton, Massachusetts, studied the behavior of 44 post-menopausal women. Half were given a perfume with the compound while the remainder used a fragrance with a placebo or dummy chemical. Only 14 percent of women using the perfume with the placebo reported an increase in affection from their partners. Biologist Winnifred Cutler, the discoverer of the mystery pheromone, is keeping the identify of the compound a secret until patents have been granted to her organization, the Athena Institute for Women's Wellness Research in Chester Springs, Pennsylvania, according to the magazine.

Proc Biol Sci. 2015. The search for human pheromones: the lost decades and the necessity of returning to first principles. As humans are mammals, it is possible, perhaps even probable, that we have pheromones. However, there is no robust bioassay-led evidence for the widely published claims that four steroid molecules are human pheromones: androstenone, androstenol, androstadienone and estratetraenol. In the absence of sound reasons to test the molecules, positive results in studies need to be treated with scepticism as these are highly likely to be false positives. One of the most promising human pheromone leads is a nipple secretion from the areola glands produced by all lactating mothers, which stimulates suckling by any baby not just their own.

Androstenone as a pheromone
Androstenone is made when the body breaks down the male sex hormone testosterone. Androstenone is in the sweat of men and women, but it is more highly concentrated in men. Androstenone facilitates the courtship behavior in females. Hiroaki Matsunami of Duke University in North Carolina and his colleague tested sweat chemicals on most of the 400 known odor receptors used by the nose to sniff out smells and chemicals. They found the odor receptor gene called OR7D4 reacted strongly with the sex steroid androstenone. Next, they tested whether variations in this gene had an impact on how people perceived the smell of androstenone in male sweat. They took blood samples and sequenced the DNA of 400 people who participated in a smell perception test. What they found is slight genetic variations determine whether androstenone has a pungent smell, a sweet, vanilla-like smell or no smell at all. The same sweat in a man can be neutral, attractive, or unpleasant to different women.

Pheromones tested in Lesbians and Gay Men
Lesbians’ brains react differently to hormones than those of heterosexual women, perhaps similar to heterosexual men. Research appears to confirm homosexuality has a physical basis and is not learned behavior.
     The research team led by Ivanka Savic at the Stockholm Brain Institute had volunteers sniff chemicals derived from male and female sex hormones. These chemicals are thought to be pheromones — molecules known to trigger responses such as defense and sex in many animals. The same team reported last year on a comparison of the response of male homosexuals to heterosexual men and women. They found that the brains of gay men reacted more like those of women than of straight men. The new study shows a similar, but weaker, relationship between the response of lesbians and straight men. Heterosexual women found the male and female pheromones about equally pleasant, while straight men and lesbians liked the female pheromone more than the male one. Men and lesbians also found the male hormone more irritating than the female one, while straight women were more likely to be irritated by the female hormone than the male one. The research was funded by the Swedish Medical Research Council, Karolinska Institute and the Wallenberg Foundation.

Dietary supplements influence
Q. I have been reading lately about claims related to "Human Pheromones" sprays or perfumes and how thay can be used to help create subconscious positive impressions about the wearer sexual effectiveness, popularity, social status etc..There are several products in the market & an industry built on these controversial claims. The vast majority of these claimed pheromones products are in the form of scented & unscented sprays.As a matter of fact, I just ordered a good collection of some of the most popular brands to put them into test, although I'm very sceptical about them ;) they costed me a fortune to tell the truth, but wanted to give them a sort of practical fair test, although it cannot be considered as a robust scientific experiment. Bought some for me, my wife, close male & female friends. Some of the latter friends are unattached & looking for partners. Few others are not very successful at the workplace. Some of them strongly believe in the existence of "Human Pheromones" & their impact. They think these things can give them substantial boosts & competitive advantages in their personal and professional lives! Will see soon how the experiment goes ;) I'm very curious when it comes to such topics & enjoy having fun in experimentation. Anyway, without going into further details or mentioning specific brands (as I don't want to involve you neither in person nor as an organization in this controversy), I found one of the products in the form of nutritional pills. Let's call it "human pheromones enhancer pills". It could probably be the only "human pheromones enhancer pills" in the market as far as I know. It's key ingredients include: L-Arginine HCI, Vitamin B-6, GABA, Tribulus Terrestris among other key and non-key ingredients. The claim here is that this mix of nutrients help the consumers release their "natural pheromones" whether those supposedly related to sexual appeal or social status in a way that they become more noticeable to people surrounding them, which, eventually, will be helpful to them!It is claimed to be a little bit more "ethical" than the sprays as the people will release their own "human pheromones" instead of spraying synthesized & concentrated ones produced in the labs.I hope that I summarized the claims correctly. Have you came across such claimed effects in your study of nutrition? Would L-Arginine HCl or tribulus for example or others separately or in a combination of nutrients help the humans release chemicals in a way that makes them appear more sexually attractive, popular or socially important in view of others who are exposed to these chemical?
   A. I am not aware of any natural herb or supplement that can make a person appear more sexually attractive or popular, but many of these natural aphrodisiacs can improve sexual desire and performance. I have not yet come across research that has looked into the influence of these herbal supplements in releasing our own pheromones.