Pau D'arco bark supplement review, side effects, clinical trials, health benefit
June 20 2017 by Ray Sahelian, M.D.

Pau D'arco ( Tabebuia impetiginosa, syn. Tabebuia avellanedae ) is a tree from South America whose inner bark has been used as an analgesic (pain reliever), anti-inflammatory, anti-cancer, anti-bacterial, and diuretic. Little research is available in the North American medical literature regarding its medicinal properties. At present it is difficult to make any clinical recommendations with certainty regarding the medicinal properties and uses of this interesting plant.

Availability, where to buy
You can find Pau D'arco in tablet or capsule form, as tea, and combined with other nutrients and herbs in many formulas. It is sold in health food stores and online.

What's in the herb?
Some of the beneficial chemicals in this plant are lapachol, glycosides, quercetin, and other flavonoids.

Beta-lapachone is found in Pau D'arco
Beta-Lapachone is a novel anticancer agent with selectivity against prostate cancer and possibly retinoblastoma and other cancers. Beta lapachone is being studied either by itself or in combination with chemotherapy drugs as a treatment for various types of cancer.

In some studies, the active phytochemicals in Pau d'Arco have been found to show strong in vitro activity against bacteria, fungi, and yeast. Pau d'Arco's may support the immune system.
Pau D'arco has antioxidant properties at a power similar to vitamin E.

Antioxidant activity and characterization of volatile constituents of Taheebo (Tabebuia impetiginosa)
J Agric Food Chem 2003.
Volatiles were isolated from the dried inner bark of Tabebuia impetiginosa. The major volatile constituents of pau darco were 4-methoxybenzaldehyde, 4-methoxyphenol, 5-allyl-1,2,3-trimethoxybenzene (elemicin), propenylbenzene (trans-anethole), and 4-methoxybenzyl alcohol. The antioxidant activity of the volatiles was evaluated using two different assays. The extract exhibited a potent inhibitory effect on the formation of conjugated diene hydroperoxides (from methyl linoleate). The extract also inhibited the oxidation of hexanal for 40 days at a level of 5 microg/mL. The antioxidative activity of pau darco volatiles was comparable with that of the well-known antioxidants, alpha-tocopherol, and butylated hydroxytoluene.

Arch Dermatol Research. 2015. Melanogenesis inhibition of β-lapachone, a natural product from Tabebuia avellanedae, with effective in vivo lightening potency. β-Lapachone is an ortho naphthoquinone obtained from the bark of the lapacho tree (Tabebuia avellanedae), which has been used medicinally for centuries. The purpose of this study was to investigate the effects of β-lapachone on inhibitory mechanism of melanogenesis. β-Lapachone inhibited melanin synthesis and tyrosinase activity at 0.8 μM in melan-a cells. Also, β-lapachone reduced the expression of tyrosinase and tyrosinase-related protein-1 at transcriptional and translational levels. The decreased expression of tyrosinase and tyrosinase-related protein-1 might result from the reduced microphthalmia-associated transcription factor (MITF) level which regulates major melanogenic proteins. The reduced level of MITF was associated with delayed ERK activation by β-lapachone. Furthermore, β-lapachone reduced melanogenesis in the human 3D skin tissue culture; besides, it dramatically inhibited body pigmentation of zebrafish and decreased melanin content and tyrosinase activity. These results show that β-lapachone may be useful as a potential depigmentation agent for various hyperpigmentation disorders.

Research studies
Constituents from the bark of Tabebuia impetiginosa.
Phytochemistry. 2004.
The bark of pau darco afforded nineteen glycosides, consisting of four iridoid glycosides, two lignan glycosides, two isocoumarin glycosides, three phenylethanoid glycosides and eight phenolic glycosides. Iridoid glycosides, phenylethanoid glycosides and lignan glycosides had ajugol, osmanthuside H and secoisolariciresinol 4-O-beta-D-glucopyranoside as their structural elements, respectively, whereas the aglycone moieties of the isocoumarin glycosides were considered to be hydroxymellein. Phenolic glycosides had 4-methoxyphenol, 2,4-dimethoxyphenol, 3,4-dimethoxyphenol, trimethoxyphenol and vanillyl 4-hydroxybenzoate as each aglycone moiety. Additionally, the sugar chains of these isocoumarin glycosides and phenolic glycosides were concluded to be beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside as well as those of osmanthuside H and above phenylethanoid glycosides.

J Ethnopharmacol. 2009. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity?. Red Lapacho (Tabebuia impetiginosa, syn. Tabebuia avellanedae), a canopy tree indigenous to the Amazonian rainforest and other parts of South America, has been acclaimed to be one of the "miraculous" cures for cancer and tumours. For the first time, during the 1960s, it attracted considerable attention in Brazil and Argentina as a 'wonder drug'. Traditionally, the botanical drug is widely used in local and traditional phytomedicine, usually ingested as a decoction prepared from the inner bark of the tree to treat numerous conditions like bacterial and fungal infections, fever, syphilis, malaria, trypanosomiasis, as well as stomach and bladder disorders.

Different species
Tabebuia altissima
Tabebuia avellanedae. β-Lapachone is a natural compound extracted from the bark of the lapacho tree.
   Molecules. 2013. Bioactive Phenylpropanoid Glycosides from Tabebuia avellanedae.
   J Ethnopharmacol. 2013. Antidepressant-like action of the bark ethanolic extract from Tabebuia avellanedae in the olfactory bulbectomized mice.
   Phytother Res. 2013. Antiulcer Effect of Bark Extract of Tabebuia avellanedae: Activation of Cell Proliferation in Gastric Mucosa During the Healing Process.
Tabebuia impetiginosa

Chem Pharm Bull (Tokyo). 2013. Synthesis and cytotoxicity on human leukemia cells of furonaphthoquinones isolated from tabebuia plants.

Does this herb provide any sexual enhancement?
    Not that I am aware of, lj100 herb is a potent aphrodisiac for better orgasm.

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Nature's Way, Pau d'Arco Inner Bark, 545 mg, 180 Veggie Caps
buy Pau D'Arco supplement

Pau D' Arco (Tabebuia altissima) is the highest quality inner bark of the Purple Lapacho tree found in Brazil and Northern Argentina. Ever since ancient times, when it was a standard for the medicine men of the Inca Empire, pau d'arco (also known as ipe roxo and taheebo) has been one of the most widely used herbs in South America. Its popularity is attributed to the active constituents, lapachol and beta-lapachone, which have been the subject of numerous scientific studies.

Buy Pau D'arco herbal supplement

Serving Size: 2 Capsules
Serving Per Container: 90
  Amount Per Serving %DV
Total Carbohydrate <1 g <1%†
Pau d'Arco (inner bark) 1.09 g **
†Percent Daily Values (DV) are based on a 2,000 calorie diet.
**Daily Value not established.

Supplement Facts:
Pau D'Arco bark  (Tabebuia altissima)
Buy Pau Darco bark, Purchase Pau Darco bark supplement