Icariin pde5 inhibitor dosage extract supplement benefit and use for erectile dysfunction or impotence treatment, extract from horny goat weed herb and review
Extract of 10%, 20%, 50%, what is the right dose? Influence on nitric oxide and blood flow, where to buy, dosage, high quality
August 6 2017 by Ray Sahelian, M.D.

Icariin, a flavonol glycoside, is an interesting substance found in certain herbs, particularly horny goat weed, known as the botanical name epimedium. Icariin has been studied as a substance that dilates blood vessels and can potentially be helpful in the treatment of erectile dysfunction. Icariin has been found to have phosphodiesterase type 5, shortened to PDE-5, inhibitor activity.
   If you have an interest in an all natural and effective herbal product that enhances libido, sensation, and erections, consider Passion Rx. This herbal formula works in men and women and results are apparent within 3 to 5 days, if not sooner.

Purchase icariin 20 percent extract from Horny Goat Weed plant, 500 mg dosage, 30 Capsules
Horny goat weed is one of the most valued tonics of Chinese herbalism. In China it is especially used for supporting healthy sexual activity - thus its name.
Horny Goat Weed product has epimedium extract (standardized to 20% flavonoids as icariin).


Buy or purchase Icariin PDE5 inhibitor, Passion Rx with horny goat weed extract, or other sexual enhancement herbs

Each pill contains:
Epimedium Sagittatum 500 mg standardized leaf extract (20% flavonoids as icariin), this means there is 100 mg of icariin in each pill

Is icariin the only ingredient in horny goat weed that is helpful for erectile function?
   A. Most herbs used for sexual enhancement have several substances that have an influence on sexual function. Icariin is the predominant substance in horny goat weed, but there are others. The right icariin dosage has yet to be determined.

Icariin and erections, PDE5 inhibitor review of research and studies
Icariin appears to have some properties similar to Viagra. Icariin is a cGMP-specific PDE5 inhibitor that may have potential in treating erectile dysfunction. It may influence nitric oxide levels.

Journal Sex Med. 2011. Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats.
Icariin treatment preserved penile hemodynamics, smooth muscle and endothelial integrity, and neuronal nitric oxide synthase expression in the penis of diabetic rats.

Potent inhibition of human phosphodiesterase-5 by icariin derivatives.
J Nat Prod. 2008. Department of Pharmacological Sciences, University of Milan, Milan, Italy.
Plant extracts traditionally used for male impotence such as Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia, and the individual compounds cinnamaldehyde, ferutinin, and icariin, were screened against phosphodiesterase-5A1 (PDE5A1) activity. Only E. brevicornum extract and its active principle icariin were active.

Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.
Asian J Andrology. 2005.

Effects of icariin on intracavernosal pressure and systematic arterial blood pressure of rat
Zhonghua Yi Xue Za Zhi. 2004.
We tested the effect of icariin on erectile function of the penis. Icariin, sildenafil and papaverine increased the intracavernous pressure in a dose-depended manner. Icariin increases intracavernous pressure.

Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities.
Asian J Androl. 2003.
We evaluated the therapeutic action of icariin on erectile dysfunction. PDE5 was isolated from human platelet and PDE4 from the rat liver tissue. The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated. Papaverine served as the control drug. Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities. Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of erectile dysfunction. For more information on phosphodiesterase inhibitor enzymes.

High Quality products formulated by a medical doctor
Mind Power Rx for better mental focus, concentration, and mood
Eyesight Rx for better vision, often within hours or days.
Prostate Power Rx for a healthy prostate gland and sexual enhancement.


Icariin side effects, safety, risk, danger with high dosage use
Icariin side effects have not yet been mentioned in the medical literature. Since icariin is not sold by itself as a supplement, we have not tested it ourselves to see if it has side effects. At present you can only find icariin as part of a horny goat weed herbal supplement. As such, the horny goat weed supplement will have many other substances within it, therefore it would be difficult to determine what role icariin, alone, would have in the horny goat weed side effect profile. Side effects of high dose horny goat weed herb include rapid heart beat and insomnia.

Icariin extracts
Epimedium is sold in various extract potencies, including various percentages of icariin and epimediosides. for instance you can find epimedium sagitattum sold by herb and ingredient suppliers as 5 percent icariin, 10 percent, 20 percent, 30 percent, 60 percent and even 90 percent. Hardly any human research has been done on these various extract concentrations to determine which are the best options for use as sexual enhancers.

Is there any difference between icariin and the group of chemicals known as icariins that are found in horny goat weed extract? I tried to purchases some of teh raw material and the one that was icariin alone was more expensive.
   Icariins contains 2-3 chemical substances, and one of these is icariin. The manufacturing process of purifying icariin takes several more stepd, thus the cost is higher than Icariins as a group of several substances.

Benefit and uses
Life Sciences. 2015. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba  Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There have been more than 260 chemical moieties identified in the genus Epimedium most of which belong to flavonoids. Icariin is the most abundant constituent in Herba Epimedii. Icariin is pharmacologically bioactive and demonstrates extensive therapeutic capacities such as osteoprotective effect, neuroprotective effect, cardiovascular protective effect, anti-cancer effect, anti-inflammation effect, immunoprotective effect and reproductive function. Particularly, the significant osteogenic effect of icariin made it a promising drug candidate in bone tissue engineering.

Alzheimer's disease
Icariin attenuates beta-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells.
Natural Neuropharmacology. 2010. Products Research Center, Korea Institute of Science and Technology Gangneung Institute, Republic of Korea;.
Our observations indicate that icariin is capable of attenuating Abeta-induced tau protein hyperphosphorylation and promoting survival of neuronal cells, meanwhile also provide some insights into the potential signaling pathway that is involved. Thus, this study promises a great potential agent for Alzheimer's disease and other tau pathology-related neuronal degenerative diseases.

Asthma, breathing
Allergol Immunopathol. 2017. Effects of icariin on asthma mouse model are associated with regulation of prostaglandin D2 level. Icariin is a promising therapeutic strategy for asthma, and PGD2 might be a new target for asthma therapy.

Icariin research as anti cancer agent
In laboratory studies, icariin appears to have anti-cancer abilities. Icariin also helps protect the liver from toxicity.

Anti-proliferative efficacy of Icariin on HepG2 hepatoma and its possible mechanism of action.
Am J Chin Med. 2009; Integrated Laboratory of TCM and Western Medicine of Peking University First Hospital and Integrated Institute of TCM and Western Medicine of Peking University, Beijing, China.
The aim of the present work was to explore the anti-hepatoma effects of icariin both in vitro and in vivo and to elucidate its potential mechanism of action. Icariin showed anticancer efficacy both in vitro and in vivo. The possible mechanism of action could be related to its anti-angiogenesis and anti-proliferative effects in tumors.

Front Pharmacol. 2016. Anti-Cancer Properties of the Naturally Occurring Aphrodisiacs: Icariin and Its Derivatives. Horny Goat Weed or Yin Yang Huo, is commonly used as a tonic, aphrodisiac, anti-rheumatic and anti-cancer agent in traditional herbal formulations in Asian countries such as China, Japan, and Korea. The major bioactive compounds present within this plant include icariin, icaritin and icariside II. Although it is best known for its aphrodisiac properties, scientific and pharmacological studies suggest it possesses broad therapeutic capabilities, especially for enhancing reproductive function and osteoprotective, neuroprotective, cardioprotective, anti-inflammatory and immunoprotective effects. In recent years, there has been great interest in scientific investigation of the purported anti-cancer properties of icariin and its derivatives. Data from in vitro and in vivo studies suggests these compounds demonstrate anti-cancer activity against a wide range of cancer cells which occurs through various mechanisms such as apoptosis, cell cycle modulation, anti-angiogenesis, anti-metastasis and immunomodulation. Of note, they are efficient at targeting cancer stem cells and drug-resistant cancer cells. These are highly desirable properties to be emulated in the development of novel anti-cancer drugs in combatting the emergence of drug resistance and overcoming the limited efficacy of current standard treatment. This review aims to summarize the anti-cancer mechanisms of icariin and its derivatives with reference to the published literature. Based on the data compiled, icariin and its derivatives are shown to be compounds with tremendous potential for the development of new anti-cancer drugs.

Experimental studies of icariin on anticancer mechanism
Zhong Yao Cai. 2000.
In order to further elucidate the reversion of malignant phenotypes of tumor cells and the mechanism of its action, highly metastatic human lung cancer cells (PG) were treated with Icariin in vitro. The results showed that icariin could influence the distribution of PG cells cycle and reduce S phase. Moreover, Icariin increased the level of cAMP in PG cells, reduced the level of cGMP and increased the cAMP/cGMP ratio. These data demonstrate that Icariin maybe a type of effective anticancer drug.

For joint health
Icariin protects murine chondrocytes from lipopolysaccharide-induced inflammatory responses and extracellular matrix degradation.
Nutr Res. 2010; School of Pharmacy, Taipei Medical University, Sinyi District, Taipei City, Taiwan, ROC.
Septic arthritis is an inflammatory arthropathy characterized by degeneration of articular cartilage. Icariin, the main active flavonoid glucoside isolated from Epimedium pubescens, is used as antirheumatics (or antiinflammatory), tonics, and aphrodisiacs in traditional Chinese medicine. In this study, we used lipopolysaccharide (LPS) to simulate the in vitro inflammatory response of chondrocytes during septic arthritis. Our hypothesis is that the icariin can protect chondrocytes from LPS-induced inflammation and extracellular matrix degradation. Our results demonstrate that icariin is a safe anabolic agent of chondrocytes. Icariin may exert its protective effects through inhibition of nitric oxide and MMP synthesis, and may then reduce the extracellular matrix destruction.

Liver fibrosis
J Ethnopharmacol. 2011. Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats.

Pharm Biol. 2013. Icariin delays homocysteine-induced endothelial cellular senescence involving activation of the PI3K/AKT-eNOS signaling pathway.

Nerve protection, effect on mind, Alzheimer's
Brain Res. 2011. Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons.

Int J Neuropsychopharmacol. 2014. Icariin, a phoshphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling.

Int J Biol Sci. 2014. Icariin Decreases the Expression of APP and BACE-1 and Reduces the β-amyloid Burden in an APP Transgenic Mouse Model of Alzheimer's Disease.

Icariin is a product contained in Horny Goat Weed in various %s such as 10, 20 and up to 90%. It has reported pro-sexual side effects relative to firmer erections and delayed ejaculations. Therefore, what would be the generally recommended % of Icarrin for an on demand use prior to sexual activity? What would be the generally recommended amount of time to consume icarrin prior to sexual activity?
    I have not studied this substance enough to know the exact answers regarding the higher percentages and little human research is available to give us much clues. As a general rule, the lower percentages need to be taken several days to be effective.

I am medical student in London, and I am doing research on sex as a whole. I was wondering if you shed some light in why some other manufacturers of Horny Weed Goat have about 60% Icariin in theirs, while yours has 10%. I am a follower of your work and please keep it up.
    Actually our new batch of hgw has 20 instead of 10 percent. I have not tested higher percentages yet but will in the future. Thanks for asking and we both wish you great success with your studies and keep us up to date on your findings and thoughts,

Some people misspell it as icarrin or icarin.

Other horny goat weed products sold online
Planetary Herbals, Horny Goat Weed, Full Spectrum, 1,200 mg, 60 Tablets