Baldness (alopecia), or severe hair loss, is much more common in men than in women. It can result from genetic factors, aging, local skin conditions, and diseases that affect the body generally (systemic diseases). Some medications, such as those used to treat cancer, also cause hair loss. Perhaps a poor diet with lots of junk food over a period of years and decades is involved, but scientists still don't have a good understanding regarding the relationship of food, diet and hair loss. A broad range of lifestyle factors, including stress (such as from divorce, marriage, childbirth, and surgery), smoking, heavy drinking, and sun exposure of the head (wearing hats while in the sun could be of help), may also foil the follicles. High testosterone levels are associated with hair loss.

Natural hair loss remedy? Diet and food
The role of diet in hair loss is not well understood, but it is possible that a diet with lots of junk food could promote inflammation and be harmful, whereas a very healthy diet, over many years, may reduce hair loss. I'm not sure whether eating soy products, lots of vegetables, fish or taking fish oils pills can be of benefit, but they certainly have other health promoting effects. Fish oils thin the blood and improve circulation. I'm not aware of a hair loss vitamin that would be useful since most Americans are not severely deficient in any particular vitamin such as vitamins A, B, C, and D. I have seen no evidence that taking a daily multivitamin in those with normal diets has an influence on hair loss or growth.

Supplements that can be harmful
High doses of vitamin A can cause hair thinning. The over the counter hormones DHEA and pregnenolone can cause hair loss.

Supplements that may help with hair growth, herbs, herbal remedies for hair thinning problems

Baicalin
Int J Mol Med. 2018. Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice. Baicalin is a traditional Chinese herbal medicine commonly used for hair loss, the precise molecular mechanism of which is unknown. In the present study, the mechanism was investigated via the topical application of baicalin to reconstituted hair follicles on mice dorsa and evaluating the effect on canonical Wnt/β‑catenin signaling in the hair follicles and the activity of dermal papillar cells. Given its non‑toxicity and ease of topical application, baicalin represents a promising treatment for alopecia and other forms of hair loss.

Saw palmetto herb and beta sitosterol
Int J Immunopathology Pharmacology. 2012. Comparitive effectiveness of finasteride vs Saw palmetto in male androgenetic alopecia: a two-year study. There were some benefits noted with saw palmetto use.

A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.
J Altern Complement Med. 2002.
One contributing factor to androgenic alopecia is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of androgenetic alopecia. The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of saw palmetto and Beta-Sitosterol, in the treatment of androgenic alopecia. Included in this study were males between the ages of 23 and 64 years of age, in good health, with mild to moderate androgenetic alopecia. The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation of beta sitosterol and Saw-Palmetto were rated as improved at the final visit.

Sulforaphane broccoli extract
Biochem Biophys Res Commun. 2016. Sulforaphane promotes murine hair growth by accelerating the degradation of dihydrotestosterone. Results suggest that sulforaphane treatment accelerates the degradation of blood DHT, and subsequently blocks the suppression of hair growth by DHT.

Equol
A molecule produced in the intestine when soy is digested stops a hormone which can fuel prostate growth or cause hair loss. Writing in the journal Biology of Reproduction, researchers said the finding could explain why Japanese men, who eat more soy, rarely have prostate cancer. They said the molecule could be used as a treatment for cancer and hair loss. The team found that the molecule, an isoflavone called equol, "handcuffs" the male hormone DHT - a by-product of testosterone. Equol is a metabolic product of the flavonoid daidzein. The researchers say this could be particularly important for men who have been diagnosed with either an enlarged prostate (benign prostatic hyperplasia), or cancer of the prostate. DHT has also been implicated in research into the causes of male pattern hair loss.
   Saw palmetto extract is also involved blocking DHT in prostate tissue, whether it does so in hair tissue is not clear. One small study indicates the combination of saw palmetto and beta sitosterol could be helpful (see below). Hopefully, over the next few years we will have a clearer understanding of the role of long term dietary intake or supplement use and hair health.

Isoflavones
Dietary isoflavone increases insulin-like growth factor-I production, thereby promoting hair growth in mice.
J Nutr Biochem. 2010. Department of Translational Medical Science Research, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.
Sensory neurons release calcitonin gene-related peptide (CGRP) upon activation. We previously demonstrated that CGRP increases insulin-like growth factor-I (IGF-I) production in various tissues of mice including the skin. Our observations strongly suggest that  might increase IGF-I production in the hair follicle dermal papilla cells in mice through increasing CGRP production in the sensory neurons, thereby promoting hair growth associated with melanogenesis in mice.

Male-pattern baldness
This is the most common type of hair loss affecting men. It's rare in women and children because it depends on the presence of male hormones (androgens), and levels of these hormones are high in males after puberty. Hair loss runs in families. Hair loss usually begins on the sides, near the front, or on the top of the head toward the back. Hair loss can begin at any age, even in the middle teen years. Some people lose only some hair and develop a bald spot in the back or a receding hairline; others, especially people whose hair loss begins at a young age, may go completely bald.
   Researchers have found that variations in a gene related to male sex hormones may be at the root of male-pattern baldness, the most common form of hair loss. The culprit is the androgen receptor gene, and it dwells on the X chromosome, which all men inherit from their mothers. Other, yet-unidentified genes are likely involved in male-pattern baldness, possibly including ones handed down by fathers. But the new findings highlight the importance of mom's side of the family when it comes to a man's hairline.

A cellular malfunction short-circuits the process by which hair follicle stem cells turn into hair-producing progenitor cells. That defect, rather than any loss of stem cells themselves, sparks the onset of androgenetic alopecia, the medical term for a type of genetic hair loss that affects both men and women, according to Dr. George Cotsarelis, chairman of the dermatology department at the University of Pennsylvania School of Medicine Cotsarelis.

Female-pattern baldness
Female hair loss is less common than male-pattern baldness. Usually, this condition causes the hair to thin in the front, on the sides, or on the crown. It rarely progresses to total hair loss.

Genetics aside, the next strongest predictor of midline (central) hair loss among women is their marital status, with the loss of a spouse (through either divorce or death) raising the risk for thinning hair above that of married or single women.

Gray Hair or grey
Hair goes gray when melanocytes become depleted. The scalp contains a reservoir of adult stem cells that provide a continuous supply of these color-making cells. But as the body ages these cells become depleted and sometimes begin to develop in the wrong part of the hair follicle. I have not yet come across credible and extensive research regarding the reversal of gray hair with vitamins or supplements, but perhaps it is possible as shown below with one herb called mucuna pruriens.

Arq Neuropsiquiatr. 2013. Darkening of white hair in Parkinson's disease during use of levodopa rich Mucuna pruriens extract powder.
   An 85-year-old patient with stable Parkinson's disease was treated with levodopa / carbidopa 250 / 25 mg tid. During a follow-up visit it was noticed that her temporal white hair was getting progressively darker, starting after introduction of mucuna pruriens extract at a dose equivalent to 1000 mg of levodopa/day. DOPA / dopamine are intermediate metabolites in the production of melanin, therefore, this association is not surprising. After the addition of decarboxylase inhibitors, this phenomenon, probably related to peripheral effects of levodopa, became strikingly rare.

Products for gray hair
Herbatint, Permanent Haircolor Gel, 2N, Brown, 4.56 fl oz (135 ml).

Common causes of hair loss
The most common is male pattern baldness due to genetics, or hereditary factors.
Telogen effluvium may follow emotional distress, such as a death in the family or a physiological stress, such as a high fever, sudden or excessive weight loss, extreme diets, nutritional deficiencies, surgery, or metabolic disturbances. Hair typically grows back once the condition that caused it corrects itself, but it usually take months.
Hormonal problems, the thyroid gland can be overactive or underactive.
When androgen hormones in the body are out of balance or people are prescribed testosterone or other androgens. Bodybuilders who take steroids could lose their hair.
Some women notice hair loss a few months after they've had a baby. During pregnancy, high levels of certain hormones cause the body to keep hair that would normally fall out. When the hormones return to pre-pregnancy levels, that hair falls out and the normal cycle of growth and loss starts again.
Excessive vitamin A intake.
Certain infections such as fungal infections of the scalp.
Certain medical conditions such as lupus or diabetes.
Alopecia areata. This is classified as an autoimmune disease, but the cause is unknown.
Traction alopecia. Excessive hairstyling or hairstyles that pull your hair too tightly cause traction alopecia.
Undergoing chemotherapy or radiation therapy may cause you to develop alopecia.
Trichotillomania is a type of mental illness in which people have an irresistible urge to pull out their hair, whether it's from the scalp, their eyebrows or other areas of the body.

Many different types of medications are thought to cause hair loss, including:
Acne medications containing vitamin A (retinoids)
Antibiotics and antifungal drugs
Antidepressants
Birth control pills
Anticlotting drugs, blood thinners, anticoagulants
Cholesterol-lowering drugs
Gout treating medications
Medications that suppress the immune system
Drugs that treat breast cancer
Epilepsy drugs (anticonvulsants)
High blood pressure medications (anti-hypertensives), such as beta-blockers, ACE inhibitors, and diuretics
Hormone replacement therapy such as testosterone, DHEA, and pregnenolone. Hair fallout is common in those who take DHEA or pregnenolone over the counter.
   Testimonial: I am a 47 year old male that has taken Propecia for over 10 years. I started taking 10mg of Dhea on Jan 1st 2014. By late February I had lost close to half the hair on the too of my head. I quit taking it March 1, 2014. I have not seen regrowth yet and my hair has turned very fine all over my scalp.
Mood stabilizers
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Parkinson's disease drugs
Steroids
Thyroid medications
Weight loss drugs

Does having sex cause hair to fall out?
   I seriously doubt there is any relation between sexual activity and balding. We do lose some omega-3 fatty acids and other beneficial substances in semen and sperm, but I doubt this would influence balding.

Natural hair growth research studies
Melatonin topical application and hair growth
Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial.
Br J Dermatology. 2004.
In addition to the well-known hormonal influences of testosterone and dihydrotestosterone on the hair cycle, melatonin has been reported to have a beneficial effect on hair growth in animals. The effect of melatonin on hair growth in humans has not been investigated so far. To examine whether topically applied melatonin influences anagen and telogen hair rate in women with androgenetic or diffuse hair loss. A double-blind, randomized, placebo-controlled study was conducted in 40 women suffering from diffuse alopecia or androgenetic alopecia. A 0.1% melatonin or a placebo solution was applied on the scalp once daily for 6 months and trichograms were performed to assess anagen and telogen hair rate. To monitor effects of treatment on physiological melatonin levels, blood samples were taken over the whole study period. Melatonin led to a significantly increased anagen hair rate in occipital hair in women with androgenetic hair loss compared with placebo. For frontal hair, melatonin gave a significant increase in the group with diffuse alopecia. The occipital hair samples of patients with diffuse alopecia and the frontal hair counts of those with androgenetic alopecia also showed an increase of anagen hair, but differences were not significant. Plasma melatonin levels increased under treatment with melatonin, but did not exceed the physiological night peak. This pilot study is the first to show that topically applied melatonin might influence hair growth in humans in vivo. The mode of action is not known, but the effect might result from an induction of anagen phase.

Q. I just read your article about the study done on woman using melatonin solution on their hair. I am a woman in her 50s and have already lost hair in the front and upper sides. I was wondering where I can get this melatonin solution for hair loss. Can you direct me to someone who can help me?

Q. I understand 0.1% melatonin hair formula can help with growing hair back for women. Where can I purchase this and would I need a prescription? I saw a website that said, "ASATEX Swiss Melatonin Hair Formula is the first topical hair product with Melatonin in a special carrier system protected by world wide patents. It is recommended for men and women experiencing short-term hair loss caused by various factors such as stress, nutritional problems and seasonal influences. ASATEX improves the texture and appearance of hair in long-term hair loss mainly due to hereditary factors. The product has been developed for use in early stages of hair loss and hair thinning."
   A. I am not familiar with this company and do not know if their product works or whether there is an adequate amount of melatonin in the hair formula.

Emails regarding hair loss
Q. I read you article on Serenoa repens saw palmetto and hair loss. What is your opinion on combining finasteride with saw palmetto given the former is a type 2 inhibitor whereas the saw palmetto is a dual inhibitor would you speculate there may be a beneficial effect on hair loss or an adverse one involving hormonal feedback loops?
   A. I don't see any obvious harm adding saw palmetto to finasteride, but I honestly don't know whether there would be a synergistic effect. I still am not convinced daily use of finasteride for hair loss or prostate enlargement is safe in the long run. Finasteride blunts sexuality.

Q. I am a 43 year old woman and took a 25 mg. DHEA supplement recommended by my doctor. He was not really clear about how long I should take it, nor did he give me any warnings about possible side effects. Unfortunately I took it for 6 months and now am experiencing pretty severe hair loss. I have lost 50% of my hair in the last 2 months. I really had NO IDEA what I was taking and feel very stupid for not researching this before I took it. My levels were tested on June 23rd and were high. I have stopped the supplement as of 3 weeks ago. Can you give me any hope (at all!) about regaining my hair once the DHEA level drops? I know you won't recommend treatments but if you could direct me to some information I would be grateful. This is causing me unbelievable anxiety.
   A. Unfortunately we have had many emails regarding hair loss associated with misuse of DHEA. There is hope that some of the hair, maybe most or all could grow back, but it is impossible to predict. Perhaps some of the herbs as mentioned above could be tried or your doctor could prescribe finasteride for hair regrowth, at least for a few weeks or months.

Q. Is there a way to test if you are an equol producer? I'm an average joe taking red clover twice a day for hair loss but also for prostate health. After reading a couple of the daizden articles I believe I have experienced my first "hot flash" the other night. I got real hot then sweat on my forehead. I just thought I had caught a touch of the flu. Anyhow, I'm now thinking that I had a hot flash, because I'm taking too much daizden? hard to say, there aren't any guidelines for how much to take. Are the "herbal" drug companies any closer to creating an over the counter equol supplement so us thinning hair people can combat male pattern baldness?
   A. You ask good questions and we just don't have enough knowledge at this time to make any firm recommendations.

Q. I receive your Supplement Research Update. Another drug to add to the list of harmful pharmaceuticals is Propecia (Merck) for hair loss. More and more people, myself included, are suffering from the long-term, potentially permanent side-effects of this hair restoring drug. The finasteride side-effects include impotence, loss of libido, hormonal imbalance, and problems with mental clarity. In my opinion, this is the next drug that the public will "blow the lid off of." I hope that Dr. Sahelian would comment on this further in upcoming newsletters. Furthermore, I was wondering if you have any recommendations for people who've been affected by Propecia. Is there a way to correct the hormonal imbalance that this drug has caused? Is there hope? I belong to a web forum called finasteride-side-effects dot com. A brief look at the messages posted here show that hundreds of people (on this site alone) have been affected.
   A. Long term studies indicate significant side effects from finasteride. A couple of options for improving libido include Passion Rx or Tongkat Ali. For mental clarity, Mind Power Rx is an option.

Q. I am a 56 year old woman. I have come through menopause but lately noticed that my hair is thinning in the front crown area of my head. Do you sell anything that might help it to thicken my hair again?
   A. I have  been looking into a good hair raising formula and thus far I have not yet found a product that I feel works effectively. But I actively looking, and if I do come across a hair raising formula, I will mention it in the newsletter.

Q. I read your newsletter with great interest. Something puzzles me: you do not mention the effect of biotin on hair growth. I am seventy, a woman, and afflicted with male pattern baldness. A dermatologist recommended 5mg (milligrams) of biotin three times a day. I confirmed this with my internist, was told it was all right, but am still a bit uncomfortable with such a high dose. I would appreciate your thought.
   A. We have not come across any reliable research regarding biotin supplementation leading to hair growth for those with age related hair loss. If your doctors have such information, we would be glad to review it.

Q. I have some personal experience with taking DHEA in 25 mg doses and also later taking finasteride (Propecia 1mg) for hair loss. There are pros and cons to each. I am a normal 44 year old Caucasian male Navy carrier pilot.
     DHEA: I took this at three different times over a few years as part of a workout supplementation program. I found that it increased my energy, sexual desire and libido, ability to lift heavy weight in the gym, and my overall feeling of strength and well being. It also significantly increased the volume and fluidity of my ejaculate and reduced sexual recovery time, letting me "stud out." It reduced joint pain due to lifting weights and trimmed me down somewhat by reducing belly fat. But it very definitely increased the rate of my male-pattern baldness and hair thinning, so I stopped taking it. It also made me irritable, impatient, intolerant, and aggressive as you would imagine with increased testosterone.
     Finasteride / Propecia: I just stopped taking this after only 13 days because it made me feel as though my prostate was drying up. It was already visibly changing my hair by increasing the area of growth, but this is not worth the negative side effects. I found it reduced my libido (which I thought would be good but felt unnatural, almost like being neutered), greatly reduced the volume of my ejaculate, induced low back pain and a sense of dryness/pain in my whole prostrate / genital region, increased my belly fat, and made me a bit lethargic.
     I never took these two hormones / drugs together. They have opposite effects in my body. DHEA was better except for the hair loss and increased aggression, as well as possible long-term contribution to prostate cancer. The only benefit to finasteride was hair improvement - everything else was very negative. I have normal to high levels of DHEA and testosterone naturally in my body. I plan to take a little DHEA to get back to neutral after quitting finasteride, then not take either one and letting my body do its own natural thing.
   A. We're impressed on how observant you are about the effects of dhea and finasteride. Our own experiences confirm your findings. One option is to take a sexual enhancement product without dhea, and thus get the sexual benefits without the hair loss effects of dhea. We have found in many propecia users that Passion-Rx reverses the sexual side effects.

Q. I have been suffering from extreme hair loss ever since puberty. I am 30 years old and I recently got a saliva test for my hormones. My progesterone was very low during the luteal phase, and my DHEAS was very high. I have been also suffering from acne, itchy scalp, horizontal ridges on my nails. I hardly have any hair left on my scalp. My doctor told me to use natural progesterone cream because my body is unable to make progesterone. I have been using the cream for 12 days a month (30 mg/day) for 3 months now and still there is no improvement.
   A. We cannot make individual recommendations, but the information on this hair web page and the page on acne should be helpful to you. The prescription of hormones bases on saliva tests is no always reliable.

Q. I saw an advertisement on the internet for a product called Advecia which is supposed to help with hair loss. Do you have an Advecia review? Does Advecia really work for hair loss?
   A. We don't have an Advecia review but can comment on the ingredients in Advecia as mentioned on their website. The Advecia website claims this product is a restorative formula for bald or thinning hair. There is a question on the website that asks, "Can Advecia assist in your individual pursuit for slowing hair loss? And they answer, "Yes." I cannot find any clinical trials with Advecia mentioned on their website. The ingredients in Advecia are saw palmetto, beta sitosterol, green tea extract, lysine, arginine, and grape seed extract. These are good nutrients and herbs, but I seriously doubt whether Advecia has a significant impact on hair loss or hair growth. The burden of proof lies with the advecia sellers and they have not provided this proof before making these claims. There is not good evdience that saw palmetto can block 5 alpha reductase is a sufficient manner in hair follicles to prevent hair loss or restore hair loss. Therefore, at this time, Advecia appears like another one of those "me too" natural hair loss product heavily advertised with no proof of effectiveness. You can find the invidivual herbs sold separately for much cheaper. There seems to be a negligible amount of saw palmetto in Advecia and a high amount of green tea extract. Until Advecia sellers present a couple of human studies proving that administration reversed hair loss, your money is better spent somewhere else. There is also a possibility of Advecia side effects with too much green tea, especially when the Advecia web site recommends taking two Advecia capsules in the evening. This could cause an Advecia side effect of insomnia.

Q. I am writing an article for a health magazine on a natural approach to prevent hair loss. Are there any natural supplements you recommend to stop hair loss?
   A. Hair loss in men is mostly due to genetics. We all know people who eat a terrible diet with tons of fast foods and soft drinks, yet they have a full head of hair while others watch their meal selection carefully and choose healthy foods on a regular basis but still can's stop their hair loss. Although genetics has most of the influence, it is possible that a low inflammatory diet over the long run could be of benefit. This low inflammatory diet would have a high intake of fish and fish oils, a high intake of all sorts of vegetables and whole grains, and a low intake of sugar and simple carbohydrates. By reducing inflammation, there would be less damage to the microcirculation that supplies nutrients to hair follicles. Furthermore, flavonoids in vegetables dilate blood vessels, and the fish oil thin the blood. As to herbs or nutrients that may help hair growth, there has been very little study in this area. I have seen one study where the combination of saw palmetto and beta-sitosterol was helpful, but many more are needed before we determine the appropriate dosage and long term benefits and risks.

Q.  I took Pregnenolone hormone for several years, one 50 mg capsule each day. For the last couple of years, I have noticed that my hair is much thinner than it used to be and I was puzzled until I read that pregnenolone could have that effect on hair. Immediately I discontinued taking pregnenolone. That was about six months ago but I have not seen any difference in my hair. If this hormone is responsible for my hair thinning, can its effect be reversed by discontinuing the use of this hormone? I am female, have always had thick hair, and am now 70 years old. My family history shows no sign of hair thinning or balding in either sex ... quite the reverse, a good head of hair into old age.
   A. The use of pregnenolone hormone or DHEA is associated with hair thinning or hair loss. In some cases the hair regrowth occurs after discontinuation of the hormones, and in other cases it may not. We are not sure if finasteride use for a few weeks would be helpful or not but that is something you could discuss with your doctor.

Q. I have thinning hair and would like to do something to prevent it. I don't really want to use something like minoxidil because of the side effects. In the searching I have done on the internet I was thinking about trying saw palmetto but then I came across something called beta sitosterol. I was wondering if Dr. Sahelian had a preference between the two and why. I was also going to try saw palmetto shampoo as I've heard the shampoo can remove DHT from the scalp. Is this true and is there a particular brand of shampoo that he recommends?
   A. I have not seen any research that saw palmetto shampoo can remove DHT from scalp hair follicles or reverse hair loss. Research with beta sitosterol and saw palmetto regarding hair growth is quite limited and at this time I have only come across one small study that showed a potential benefit with the combination of saw palmetto and beta sitosterol.

I am a 48 year old woman who is going through surgical menopause. Would it be safe for women to take Prostate Power Rx to see if would help stop hair loss?
    Thus far we have not had any negative feedback from women who have used this natural supplement, but it is not possible for us to predict the safety of use in any one individual woman.

I have cystic fibrosis and would like to start taking oral glutathione in hope that it may raise my bodies glutathione levels and because some cystic fibrosis patients mention it seems to increase their appetite. I take whey protein powder which contains tyrosine. I have read on the internet on so many different websites that if you take Glutathione and l-tyrosine together that your hair can turn white. I dont want my hair to grey before its time.
   I have not seen any reliable studies that indicate this problem would occur.

Does ozone water cause or cure grey hair? And does it help hair to grow?
   A. I have seen not such research regarding the influence of ozone water on growth or reversal of grey color.

Dry hair cause
These are the primary external causes
Harsh shampoo
Shampooing too often
Hair perms
Chlorine in swimming pools and hot tubs
Overuse of the blow dryer or curling iron
Too much exposure to sun and wind
High mineral content in local water supplies
Too much brushing

Treatment
Use a high quality conditioner.
Try a few drops of lavender and sandalwood essential oils mixed with a few ounces of warm sesame or soy oils then rub the oil to the hair, wrap in a towel for 10 minutes, then rinse.
Perhaps eating more fish and flaxseed, or taking the oils could help.

Natural hair growth products sold over the counter, Viviscal, AminoMar
Q. What is your opinion of Viviscal for thinning hair? It contains AminoMar marine comples, apple extract powder, biotin vitamin, vitamin C and L-ccystine and l-methionine.
   A. I don't have personal experience using Viviscal, but I found some studies. I do not know what is in AminoMar. I saw an article online that said, "The brand’s signature AminoMar marine complex, a blend of both sustainably sourced shark powder and mollusk powder."

J Cosmet Dermatology. 2016. A 6-month, randomized, double-blind, placebo-controlled study evaluating the ability of a marine complex supplement to promote hair growth in men with thinning hair. An oral nutraceutical supplement based on a marine complex formulation has previously been reported to significantly increase the number of terminal hairs in women with thinning hair. The objective of this double-blind, placebo-controlled study was to confirm the beneficial effects of a similar marine complex supplement in adult male subjects with thinning hair (Viviscal Man; Lifes2good, Inc., Chicago, IL, USA). Healthy adult male subjects with thinning hair associated with clinically diagnosed male pattern hair loss were enrolled and randomized to receive study drug or placebo twice daily. At Day 90, subjects indicated a significant improvement in three of six quality of life measures as well as a significant overall improvement in quality of life. After 180 days, significant increases were observed for total hair count, total hair density, and terminal hair density. The investigator assessments revealed significant improvements in terminal and vellus hair count and terminal hair density. Hair pull test results were significantly lower (fewer hairs removed) for study drug vs. placebo at Days 90. There were no reports of treatment-emergent adverse events. The results of this study showed for the first time that a natural dietary supplement containing a marine complex and other ingredients can decrease hair shedding and promote hair growth in men with thinning hair.

Dermatol Res Pract. 2015. A 3-month, randomized, double-blind, placebo-controlled study evaluating the ability of an extra-strength marine protein supplement to promote hair growth and decrease shedding in women with self-perceived thinning hair.

J Int Med Res. 1992. A comparative study of a new food supplement, ViviScal, with fish extract for the treatment of hereditary androgenic alopecia in young males.

Procerin
Q. I am planning to use an all natural regrowth formula called Procerin and wanted to know if it has side effects. Procerin is a proprietary blend of herbal, mineral, and vitamin components with Saw Palmetto Berries, Gotu Kola, Nettles, Magnesium, Zinc Sulfate ,Eleuthero Root, Vitamin B-6, Pumpkin Seed Meal, and Muira Puma Root. Procerin XT Topical Foam ingredients include Water, Cocamidopropyl Betaine, PEG-40 Hydrogenated Castor Oil, Saw Palmetto Extract, Rooibos Leaf Extract, Grape Seed Extract, Linoleic Acid, Oleic Acid, Evening Primrose Oil, Avocado Oil, Panthenol, Niacin, Azelaic Acid, Tocopheryl Acetate, Zinc Sulfate, Peppermint Oil.
   As of 2016 I have not seen clinical trials with Procerin.