Gluconate information and review of benefit
October 24 2015 by
Ray Sahelian, M.D.

Gluconic acid is made by the oxidation of the first carbon of glucose Gluconic acid has the chemical formula C6H12O7. When dissolved in water, gluconic acid forms the gluconate ion C6H11O7-. The salts of gluconic acid are also known as gluconates.

Where do you find gluconate or gluconic acid
Gluconic acid is found naturally in fruit, honey, kombucha tea and wine and is used as a food additive, an acidity regulator.

Supplements and their cost
Many supplements now have a gluconate joined to the molecule, the following are some examples.
Calcium Gluconate Monohydrate USP $2/kg
Copper Gluconate Anhydrous USP $7/kg
Creatine Gluconate $7/kg
Magnesium Gluconate Dihydrate USP $4/kg
Manganese Gluconate Dihydrate USP $4.5/kg
Potassium USP $3/kg
Zinc Gluconate Dihydrate USP $4.5/kg
   As you can see above, creatine now comes in gluconate form, even though it is most often known as creatine monohydrate. Is there an advantage to ingesting creatine gluconate versus monhydrate? What about calcium gluconate versus calcium citrate? Until human studies are done, it would be difficult to know which form of a mineral or amino acid is better. My initial thought is that, for practical purposes, there would not be much of a difference. This is just a guess.

Int J Occup Med Environ Health. 2014 Jan 24. Clinical arterial infusion of calcium gluconate: The preferred method for treating hydrofluoric acid burns of distal human limbs. Arterial infusion of calcium gluconate, effectively relieving the pain, blocking wound progressive deepening, and causing no adverse effects, could be the preferential method to treat hydrofluoric acid burns of the distal human limbs.

BMC Musculoskelet Disord. 2015 May 13. Effectiveness of intra-articular injections of sodium bicarbonate and calcium gluconate in the treatment of osteoarthritis of the knee: a randomized double-blind clinical trial.