Definition: A cytokine is a small protein released by cells that has a specific effect on the interactions between cells and on communications between cells. Cytokines include a number of groups which are called interleukins, lymphokines and cell signal molecules, such as tumor necrosis factor and the interferons, which trigger inflammation and respond to infections. There are both pro-inflammatory cytokines and anti-inflammatory cytokines. They are involved in almost every disease, and the manipulation of cytokine levels through diet or natural herbal supplements is an exciting field to explore. For instance, the flavonoid luteolin could reduce cytokine levels.
Cytokines and depression, mood changes
Clinical and experimental studies indicate that stress and
depression are
associated with the up-regulation of the immune system, including increased
production of pro-inflammatory cytokines. When administered to patients or
laboratory animals, some of these cytokines induce typical symptoms of
depression. It is known that cytokines influence brain
neurotransmitters and the
activity of the hypothalamic-pituitary-adrenal axis, both of which are disturbed
in depression. Therefore some cases of low mood and low energy / motivation are
due to elevated levels of these proteins.
Influence of dietary supplements, herbs, vitamins
Supplementation with omega-e fatty acids, mostly found in fish and fish
oils, can help reduce cytokine production.
Q. Can you tell me if saw
palmetto or the herbal extract curcumin
reduce cytokine levels?
A. It appears in some studies that curcumin can reduce
serum TNF-alpha and interleukin levels. We have not seen studies
regarding the interaction of saw palmetto with cytokines.
I just had a cytokine test done on my levels of
cytokines, and 6 out of 8 were undetectable: IL 2,4,5,10,12,Tnf a. But
IL 6 and Gamma interferon were in the normal ranges. I have long term
severe CFS chronic fatigue syndrome. Things I used to be able to take
now make me much more tired, bedridden, with a flu like malaise. Even things like beta
carotene, vitamin A, NAC, ALA, antiviral and antibacterial herbs,
immune boosters, B12, probiotics. The list goes on. I can take Co q10,
vitamin E, PPC, PPS, Fish oil, enzymes, and other things. The normal CBC with Differential/Platelet tests
like neutrophils, basophilss, WBCs etc., were all normal. So, its the
cytokines I lack. Any idea would be greatly appreciated, for I am mostly
bedridden now.
A. There is not research enough yet to know exactly how to manipulate
different ones and for practical purposes that is not as important as
taking a comprehensive dietary and lifestyle changes that have an
overall global influence on inflammatory markers in the body.
Echinacea and Cytokines
Cytokine production in leukocyte cultures during therapy with Echinacea
extract.
J Clin Lab Anal. 1996.
We measured the levels of the cytokines IL-1-alpha, IL-1-beta, IL-2, IL-6,
TNF-alpha, and IFN-gamma in culture supernatants of stimulated whole blood cells
derived from 23 tumor patients undergoing a 4-week oral treatment with a
spagyric extract from Echinacea angustifolia, Eupatorium perfoliatum, and Thuja
occidentalis (Echinacea complex). All patients had had curative surgery for a
localized solid malignant tumor. Blood was taken before treatment and after 2
and 4 weeks of therapy. Twelve untreated tumor patients at the same clinical
stage, also after curative surgery, served as a control group. In the blood cell
cultures of all patients, a rather wide range of cytokine levels was found.
After therapy with Echinacea complex, no significant alteration in the
production of the cytokines could be seen in comparison to the controls, and
also the leukocyte populations remained constant. We conclude that at this
application and dosage, the therapy with Echinacea complex has no detectable
effect on tumor patients' lymphocytes activity as measured by their cytokine
production.
Garlic influence
Urol J. 2014. The effect of garlic powder on human urinary cytokine
excretion. To evaluate the effects of orally administered dehydrated garlic
powder on cytokine excretion in the urinary tract. A total of 60 healthy
volunteers, randomized into 3 groups, were given a single oral dose of 1 g or 3
g of dehydrated garlic powder or placebo. Oral intake of doses of garlic
traditionally used for daily supplementation increases urinary levels of IL-12,
which is a potent stimulator of T helper cell 1 (Th-1) immune responses. This
observation encourages further studies investigating the immunostimulatory role
of garlic in the urinary tract.
Cytokine and Allergy
Allergic diseases have been closely related to Th2 immune responses,
which are characterized by high levels of interleukin IL-4, IL-5, IL-9 and
IL-13. These cytokines orchestrate the recruitment and activation of different effector cells, such as eosinophils and mast cells. These cells along with Th2
cytokines are key players on the development of chronic allergic inflammatory
disorders, usually characterized by airway hyperresponsiveness, reversible
airway obstruction, and airway inflammation. Accumulating evidences have shown
that altering cytokine-producing profile of Th2 cells by inducing Th1 responses
may be protective against Th2-related diseases such as asthma and allergy.
Cancer Treatment
Cytokine -based immunotherapy has been investigated for cancer treatment.
However, so far most cytokine -based therapy trials have fallen short of
expectations. One of main obstacles is the difficulty to achieve therapeutically
relevant dosage in patients without generating excessive normal tissue toxicity.
Fever
When infection occurs, white blood cells send cytokines to marshal defenses in
the body. Cytokines tell blood vessels in the brain to make a second hormone,
prostaglandin E2. Prostaglandin E2 acts on the hypothalamus, an area of the
brain that controls basic functions like eating, drinking, sex and body
temperature. Aspirin acts on all prostaglandin receptors in the body.
Cytokines and heart disease
There is an association between increased heart disease with proinflammatory
cytokines. Many germs including bacteria, protozoa and viruses have been
associated with heart disease in patients, and are able to induce similar
disease in animal models. Recognition of germs by the innate immune system leads
to release of proinflammatory cytokines that both reduce infection and increase
chronic inflammatory heart disease.
Congestive heart failure
Elevated circulating concentrations of proinflammatory cytokines may
contribute to the pathogenesis of congestive heart failure (CHF). In vitro
studies suggest that vitamin D suppresses proinflammatory cytokines and
increases antiinflammatory cytokines. There may be an impaired vitamin
D–parathyroid hormone axis in the progression of CHF.
Repetitive Motion chronic pain
Early nerve damage caused by repetitive motion on the job can cause "sick
worker" syndrome, a fatigue or depression that can be mistaken for poor work
performance.
The study done on rats found that nerve injuries caused by low-force, highly
repetitive movement -- a condition called repetitive strain injury, which is
common to typists, pianists and meatpackers, among other professions -- can be
blamed on increased production of proteins known as cytokines. Cytokines show up
in injured nerves as early as three weeks after the first signs of cell stress.
Cytokines also are known to spark symptoms of malaise and the study concludes
that an onslaught of these proteins affected the rats' psychosocial responses.
With so many cytokines entering the blood stream so early, some apparently
traveled to the brain, sparking the rat version of "sick worker" syndrome.
Cytokines and Chronic Pain
Low blood levels of two anti-inflammatory proteins could be key to
chronic pain. Low
concentrations of two cytokines, IL-4 and IL-10, were found in patients with
chronic widespread pain, according to a German study published in the
2006 issue of Arthritis & Rheumatism. Cytokines are proteins that act as
messengers between cells. The study included 40 patients who'd received
intravenous immunoglobulin (IVIG) as a novel treatment for pain that hadn't
responded to standard therapy and another 15 patients who did not receive IVIG.
The study also included a control group of 40 healthy people. Blood samples were
collected from all the study volunteers, and the pain patients were asked to
rate their pain, fatigue, mood and cognitive function. Compared with the control
group, the 40 pain patients had significantly lower levels of the cytokines IL-4
and IL-10. The 15 patients in the second group had similar results, although the
difference in their levels of IL-10 compared to people in the control group was
not statistically significant. Several factors may be involved in low levels of
these cytokines and how they influence pain, the study authors said. They noted
that previous studies have shown that IL-10 reduces sensitivity to pain and that
IL-4 can also dull pain response.
Cytokine modifying biologic drugs
Humira (adalimumab), Remicade (infliximab), and Enbrel (etanercept) are
rheumatoid arthritis drugs and have comparable effectiveness and safety. These
biologic drugs either block or supplement immune system chemicals called
cytokines. The three drugs all work by blocking a cytokine called tumor necrosis
factor. Biologics, however, also have the potential for rare but severe side
effects such as serious infections or cancers. Another biologic drug, Kineret (anakinra),
which blocks a cytokine called interleukin-1, appears to be less effective than
the other three drugs. Journal of Rheumatology, 2006.