Creatinine levels ways to lower naturally
August 10 2017 by Ray Sahelian, M.D.

Creatinine levels usually rise with worsening of kidney disease. It is important to first determine the cause of the elevated levels before starting any type of traditional or natural therapy.

Creatinine Research, ways to lower naturally
Acacia gum supplementation of a low-protein diet in children with end-stage renal disease.
Pediatric Nephrology. 2004.
Patients with end-stage renal disease (ESRD) die in the absence of renal replacement therapy (RRT). In developing countries RRT is not uniformly available and treatment often relies on conservative management and intermittent peritoneal dialysis (IPD). This study investigates the possibility of using acacia gum supplementation to improve the quality of life and provide children with ESRD with a dialysis-free period. Three patients referred to our hospital with ESRD during a 3-month period were enrolled in a therapeutic trial to investigate the efficacy of acacia gum (1 g/kg per day in divided doses) as a complementary conservative measure aimed at improving the quality of life. Inclusion criteria included a pre-dialysis creatinine clearance of <5 ml/min, current dietary restrictions and supplementation, at least one dialysis session to control uremic symptoms. One patient complied with the protocol for only 10 days and died after 6 months, despite IPD. Two patients completed the study. Both reported improved well-being. Neither became acidotic or uremic, and neither required dialysis during the study period. Both patients maintained urinary creatinine and urea levels not previously achieved without dialysis.

Comparison of a vegetable-based (soya) and an animal-based low-protein diet in predialysis chronic renal failure patients.
Nephron. 1998. Soroka N, Silverberg DS, Greemland M, Birk Y, Blum M, Peer G, Iaina A. Department of Nephrology, Tel Aviv Medical Center, Israel.
There is some experimental evidence to suggest that progression of chronic renal failure is slower on diets based on soya protein than on diets based on animal protein. We have compared the effect of a soya-based vegetarian low-protein diet and an animal-based low-protein diet in 15 patients with CRF. 15 patients with CRF (51Cr-EDTA-measured glomerular filtration rate 15-50 ml/min/1.73 m2) were studied. In a randomized crossover trial, the patients were given each diet (each containing 0.75 g protein and 32 kcal per kilogram body weight) for a 6-month period. Blood urea nitrogen, urine urea nitrogen, protein catabolic rate, and 24-hour urine creatinine and phosphate were lower on the vegetarian low-protein diet than on the APD. The 24-hour protein excretion was similar on the two diets. The two low-protein diets resulted in a slowing in the progression of CRF. A vegetarian low-protein diet is well tolerated in CRF and is associated with lower protein and phosphate intakes and a higher caloric intake than an animal-based low-protein diet and may, therefore, be used as a safe alternative or partial substitute for the usual animal-based low-protein diet in CRF.

Defintion - Creatinine is creatine anhydride, C4H7N3O, formed by the metabolism of creatine (a compound made of three amino acids) that is found in muscle tissue and blood. Creatinine is excreted in the urine as a metabolic waste. Elevated blood levels indicate that the kidneys are not able to eliminate fast enough.

Causes of high creatinine levels in the blood
Creatine use as a supplement

Drugs particularly chemotherapy medicines such as cisplatin

Kidney disease

Testimonial received in 2017
I am in Wellington, in the country of New Zealand. I would like to share with you my reporting to CARM (our Centre for Adverse Reactions Monitoring) of raised creatinine levels which occurred twice with DHEA self-administration, initially and upon rechallenge. This effect of DHEA on creatinine has been reported in the medical literature. Last year I was on a stabilised regime of enalapril 30mg/d for hypertension. Creatinine was within normal range throughout enalapril administration. After adding DHEA 100 mg/d (obtained via prescription from a reliable compounding pharmacy), my creatinine rose rapidly, over several days, to 156 umol/L (SI units, range 60-110 umol/L). This was associated with severe symptoms of polyuria. My serum potassium at the time was also mildly elevated at 5.3 mmol/L (SI units, range 3.5-5.2 mmol/L), probably due to the reduced renal function. I stopped the DHEA and reduced my enalapril dose to 20mg/d. Creatinine returned to normal. The thiazide diuretic bendroflumethiazide was added at 2.5mg/d to augment the antihypertensive effect of the enalapril. Creatinine remained within normal range for some months. I restarted DHEA recently at the same dose of 100 mg/d. Creatinine rose above normal again, this time at 118. There were no significant urinary symptoms associated with this smaller elevation. Serum potassium was normal. I maintained the DHEA and bendroflumethiazide doses, and decreased the enalapril to 10mg/d. After some 6-8 weeks, my creatinine has returned to normal at 85. I continue to take DHEA 100mg/d. Below is a copy of an email I sent to CARM appending to my online report of this to them. I am aware that you do not personally recommend DHEA supplementation at doses of the magnitude of 100mg/d.

  Appending to my report: DHEA (dehydroepiandrosterone, prasterone) is classified in New Zealand as a Section 29 Prescription Only Medicine. There will be many patients here importing DHEA of questionable grade from overseas, as well as patients sourcing prescriptions of DHEA from medical practitioners which is then sourced from a compounding pharmacy, as there are many claims regarding this drug on the Internet, and it is classified as a 'supplement' in many countries and regarded as such by many who experiment with it. Not enough is known about adverse effects and very little about long-term effects of DHEA administration. Prior to self-dosing with DHEA, I was not aware of its renal adverse effects despite consulting the monograph on Medscape. I believe many physicians prescribing it and the many patients 'supplementing' with it will also be unaware of its renal effects and complete adverse effect profile. The elevation of creatinine I report here will have also been due to the concomitant medications enalapril and bendroflumethiazide, though initially and upon [re]challenge prasterone (DHEA) appeared to produce an additive or synergistic elevation of creatinine to above the upper limit of normal, and after initial administration associated symptoms of severe polyuria where creatinine was more significantly elevated.(3) Attached one PDF file of article which describes elevation of creatinine with DHEA

Diabetic Nephropathy
Creatinine levels are elevated in patients who have diabetic nephropathy. Management of hypertension is the mainstay of prevention and treatment of diabetic renal disease. Tight blood pressure control slows renal disease progression in established diabetic nephropathy.

Creatinine elevation due to Contrast Material
The administration of iodinated contrast media is integral to many cardiovascular procedures. While it is clear that contrast media provide significant diagnostic benefit, there is some risk of contrast medium-related adverse events in a small percentage of patients. Potentially the most serious complication associated with the use of iodinated contrast agents is contrast-induced nephropathy (CIN). Most patients undergoing contrast-enhanced radiographic procedures are not at risk for CIN, however subjects with pre-existing renal insufficiency, diabetes mellitus, or cardiovascular disease receiving intra-arterial administrations of contrast material are at increased risk. Typically, patients with CIN will experience changes in serum creatinine 1-5 days following contrast exposure.

Reliable serum creatinine measurements in glomerular filtration rate (GFR) estimation are critical to ongoing global public health efforts to increase the diagnosis and treatment of chronic kidney disease.

Q. I have elevated creatinine level at 1.4 from my lab report. Is there anything I can do to bring this down?
     A. There are many reasons why creatinine levels are elevated. Your doctor needs to do a complete medical exam and blood work.

Q. Is there such a thing as a creatinine supplement?
   A. No. People sometimes confuse creatine with creatinine. There is no creatinine supplement but there is a creatine supplement available as powder or pills, often combined with other ingredients in a muscle building product.

Q. My employer does random drug tests. I do not use drugs or alcohol. On my tests my creatinine level has been low. I guess that low creatinine can mean that someone is drinking a ton of fluids to try to flush their system to hide drugs or alcohol. I only drink about 4 12 oz bottles of water a day. This is not excessive I think. So they are concerned that something is up maybe medically since they do not believe for a moment that I am using drugs. I’ve worked here for 15 years without ever having a major screw up or meltdown. So they want an explanation for the low creatinine so they can tell their insurance company to appease them. I have been looking into and found what I think is the reason for it. I believe my creatinine is low because I am a vegetarian. I found your articles on the internet so I thought I would give them to them which I did. The insurance company said something found on the internet is not real proof. Do you have an actual article, book I can buy or something that I could get directly from you so that I can get my job out of jeopardy? My company is afraid that if they just let me remain here and if someone who is actually using drugs tries to flush their system and also has “low creatinine” that that person can sue the company for discrimination if they are fired for low creatinine which can show a possible attempt to adulterate a urine sample, but I am not let go because my company knows I do not use drugs.