Cnidium extract side effects, benefit for better sexual pleasure, extract health benefit by Ray Sahelian, M.D.
April 10 2016

Cnidium monnieri is a plant which grows in China (and possibly in Oregon) whose seeds are used in classical traditional Chinese medicine for skin problems and as a natural libido booster. It is known in China as She Chuang Zi. You may find cnidium seeds in bulk at Chinese pharmacies and some health food stores. Cnidium is found in an effective sexual enhancement product called Passion Rx.

What's in cnidium monnieri herb, what chemicals does it contain?
Cnidium seed contains several compounds including coumarins osthol or osthole, xanthotoxol, imperatorin, bergapten, monoterpene polyols, glucides and hepatoprotective sesquiterpenes. Osthole has been found in studies to have anti tumor activity and to be helpful in strengthening bones.

Passion Rx  with cnidium extract -- For Men and Women

How quickly does this natural formula work?
Passion Rx provides results that are sometimes seen by the second day, but continue to improve with use. Our feedback thus far indicates more than 80% user satisfaction by the end of the first week, and 90 percent by the end of the second week.
Dr. Ray Sahelian, M.D. and his research staff have tested various doses and extracts of exotic herbs from a number or raw material suppliers to determine the ideal dose and combination for optimal libido enhancement with fewest side effects. After years of trial and error, a proprietary blend with 11 herbal extracts, has been created which works within hours. This unique blend is a close kept secret known only to Dr. Sahelian and his research staff.


Purchase Passion Rx with cnidium extract sexual enhancer, to see a list of dozens of aphrodisiac herbs
The potent herbal extracts in this sex pill include acetylcarnitine, ashwagandha, catuaba, choline, cnidium, coleus forskohlii, damiana, DMAE, horny goat weed herb, maca herb, mucuna pruriens herb, muira puama herb,  passion flower herb, rehmannia herb, rhodiola extract, shilajit substance, suma herb, tribulus, and tongkat ali. A version of Passion Rx has yohimbe extract.

Benefit of Cnidium for Impotence or erectile dysfunction treatment
In rabbits, a coumarin compound found in cnidium called osthol or osthole was found to help relax the corpus cavernosa of the penis, which would potentially help with blood flow in those with erectile dysfunction.

Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.
Planta Med. 2001.
Four known coumarins, osthole, imperatorin, xanthotoxin, and isopimpinellin from the ethanolic extract of the fruit of Cnidium monnieri exhibited relaxing effect In phenylephrine-precontracted endothelium-intact rabbit corpus cavernosum.

Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue in vitro. J Urol 2000.

Side effects
No major cndium side effects have been reported in the medical literature. High doses could cause sleep disturbance and fast heart beat.

Benefit, research review
Preliminary studies show some of the compounds in cnidium monnieri may have anti-histamine, anti-itch, anti-fungal, and anti-bacterial effects, along with having an influence on the pituitary-adrenocortex axis.

Bone strength
Studies on rodents indicate that cnidium monnieri may improve bone strength (coumarins from fruits of cnidium monnier inhibit formation and differentiation of multinucleated osteoclasts of rats).

I am interested in taking cnidium herb for the strengthening of bones, I read in your info that it was helpful. Is there something else that would be better? Is it good for women or just men? Is it a blood thinner? Do you offer it by itself? Can it be taken safely along with an ACE inhibitor for blood pressure?
    Hardly any human studies have been done with this plant so it is difficult to answer these questions. There are many other dietary supplements that have been evaluated for bone health and osteoporosis treatment.

Coumarins from Cnidium monnieri and their proliferation stimulating activity on osteoblast-like UMR106 cells.
Pharmazie. 2004.
Three coumarins (osthole, bergapten and imperatorin) were isolated, and their effects on osteoblastic proliferation were investigated. Osthole, a major pharmacologically active constituent, significantly promoted the cells' activity. Bergapten and imperatorin were less effective than osthole. These results suggested Cnidium monnieri extracts might have potential activity against osteoporosis, and its chloroform fraction might contain active constituents stimulating osteoblasts.

Cancer and anti tumor potential
Cnidium monnier may have anti-cancer properties.

Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines.
Taipei Medical University, Taipei, Taiwan. Planta Med. 2003.
Cnidii monnieri Fructus is used as a tonic agent in traditional Chinese medicine. In a previous Chinese herb-cytotoxicity screening test, the ethanol extract of cnidium monnieri exhibited strong effects on human leukemia (HL-60), cervical carcinoma (HeLa) and colorectal carcinoma cells. Then, the cnidium monnieri extract was subjected to silica gel column chromatography and recrystallization to give five coumarins: osthol, imperatorin, bergapten, isopimpinellin, and xanthotoxin. Among these compounds, osthol showed the strongest cytotoxic activity on tumor cell lines. Our results indicate that osthol and imperatorin can induce apoptosis in HL-60 cells.

High Quality products formulated by a medical doctor
Consider highly popular all natural products.
Mind-Power-Rx for healthy brain function and memory with DMAE and Ginkgo biloba. It also includes acetyl l-carnitine and the herb
bacopa for brain enhancement, and for mind and memory support.
Diet Rx with 5-HTP helps increase the levels of serotonin in the brain, which helps you eat less. It does curb appetite.
Eyesight Rx for healthy vision, results sometimes seen within hours.
MultiVit Rx a daily comprehensive multivitamin for more energy and vitality.
Joint Power Rx
for healthy joint support with glucosamine and chondroitin sulfate>
Prostate Power Rx - for healthy prostate gland and better erection.

CoQ10 50 mg for healthy energy metabolism and heart function.
Curcumin the active extract from turmeric, found in curry spice
Tongkat Ali 200 mg herbal libido enhancer from Malaysia
Mangosteen contains powerful xanthone antioxidants
Serrapeptase has anti-inflammatory benefits

Lung health, benefit for COPD?
Chin J Nat Med. 2014. Inhibitory effects of Cnidium monnieri fruit extract on pulmonary inflammation in mice induced by cigarette smoke condensate and lipopolysaccharide.

Cnidium is available in bulk powder, however it is currently not easily found by itself as a supplement. it is most often found in combination with other libido herbs in formulations. Cnidium herb is also available in different extract potencies, for instance a 4 to 1 extract and a 10 to 1 extract. You will also find cnidium extract sold as a 30 percent osthole extract.

Cnidium research
Osthole improves aspects of spatial performance in ovariectomized rats.
Am J Chin Med. 2004.
The present study was designed to investigate the ameliorating effects of cnidiuim monnieri L. Cusson and osthole, a constituent of Cnidiuim monnieri, on the spatial performance deficit in scopolamine (SCOP)-treated or ovariectomized (OVA) rats. Cnidiuim monnieri improved the deficit of spatial performance, and reversed the lower plasma estradiol levels caused by SCOP in female rats. We find that osthole is an active constituent of cnidiuim monnieri, and possesses ameliorating effects on the spatial performance deficits in SCOP-treated female rats or OVA rats. The action mechanism of the effects of osthole on performance deficits was related to the estrogen-like properties and activating the central cholinergic neuronal system.

Mechanism of the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri Zhongguo Zhong Yao Za Zhi 1990.
Anti-allergic effects of cnidii monnieri fructus (dried fruits) and its major component, osthol. Biol Pharm Bull. 2002.

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Books written by Dr. Sahelian include those on mental power enhancement and sexual pleasure increase

Q. I did a search for Passion Rx in google and came across a website that was selling Viastat. Can you tell me more about Viastat, is there a review that you have that i can read? I saw that it has cnidium in it.
   A. We generally prefer not to comment on other products. We have not tried Viastat so we don't have a review. This sexual product has eurycoma longifolia and cnidium monnieri. These herbs and herbal extracts are legitimate sex herbs, but we don't know if the combination is effective or whether Viastat has side effects or what the appropriate the appropriate dose would be.

I have seen cnidium monnier and monnieri spellings. Which is right?
    The few studies published on this herb that we have seen mention it as monnieri, but we have also seen it spelled as cnidium monnier.