Carnitine
supplement
health benefit and side effects, helps improve energy and useful for heart tissue
Does this nutrient help with weight loss? What is the right daily dosage, is it
100 mg, 200, 250, 500, or 1000 mg
Research studies with propionyl l carnitine, and other forms such as tartrate
and fumarate
June 22 2017
by
Ray Sahelian, M.D.
L-carnitine is a naturally
occurring substance found in most cells of the body, particularly the brain,
neural tissue,
muscle, and heart. Carnitine, whose structure is similar to choline, is widely available
in animal foods (meat, poultry, fish and dairy products), whereas plants have very small amounts. Most
non-vegetarians consume about 100 to 300 mg of carnitine a day, and the body is able to
synthesize this nutrient if dietary intake is inadequate. Ninety-five percent of
the body's carnitine pool resides in skeletal muscle where it plays a vital role
in fuel metabolism. Vegetarians obtain negligible amounts of this important
nutrient from their
diet.
When ingested as a pill, carnitine is not able to cross the blood-brain barrier as well as its activated form
acetylcarnitine
which
has a more noticeable mental effect and
usually enhances mental clarity and focus, along with slight mood elevation.
The effects of carnitine tend to be more physical than mental, in the sense that
it provides enhanced physical energy. Both nutrients are wonderful antioxidants
are are crucial for optimal health.
Advance Physician Formulas, L-Carnitine, 500 mg,
30 Capsules
Buy L-Carnitine 250 or 500 mg capsules or Diet Rx appetite suppressant or Mind Power Rx brain booster
Supplement Facts | ||
Serving Size: 1 Capsule | ||
Servings Per Bottle: 30 Capsules | ||
Amount Per Capsule | % DV | |
L-Carnitine | 500 mg | † |
† Daily Value or Recommended Daily Intake not
established. |
Dosage, how much to take
Although many people find
250 mg to 500 mg to be the threshold where they notice
the benefits, others may notice the positive effects on less.
Buy L Carnitine 500 mg per capsule for more
energy
Acetyl l carnitine 300 mg per capsule
Diet Rx appetite suppressant
Mind Power Rx brain booster
Carnitine is sold by itself as a single nutrient in a bottle. It can be found in
vitamin stores, on the internet, and many pharmacies or drug store chains. A
number of natural products promoted for improving energy may contain it
along with other vitamins and herbs.
Buy Carnitine supplement product, Diet Rx appetite
suppressant, Mind Power Rx for better mental focus and
concentration, Acetyl l carnitine mind boosting pills, Passion Rx effective
sexual enhancer, or Eyesight Rx for better
vision
Mind Power Rx natural brain enhancer
This natural mental stamina enhancer is a sophisticated cognitive formula with a dozen brain herbs and nutrients. It combines a delicate balance of brain circulation agents and neurotransmitter precursors with powerful natural brain chemicals that support healthy:
Memory and Mood
Mental clarity
Concentration
Alertness and Focus
Why buy all the individual herbs and nutrients separately
when you can buy this excellent combination?
The herbs in mental energy boosting product include: Ashwagandha, Bacopa, Fo-Ti,
Ginkgo biloba, Ginseng, Gotu kola, Mucuna pruriens, Reishi, and Rhodiola.
The nutrients and vitamins in Mind Power Rx include Acetyl-l-carnitine, Carnitine,
Carnosine, Choline,
DMAE, Inositol, Methylcobalamin, Pantothenic acid,
Tyrosine, and Vinpocetine.
What's the right dosage?
Since each person has a unique biochemistry, dosage recommendations vary. A
range of 50 to 500 mg daily works for most people. Take a day
or two off each week. The effects of carnitine accumulate over time, therefore
your dosage may need to be reduced or you may wish to take breaks more often.
Much depends on whether you are taking other medications and supplements. If you
are already taking natural products that increase energy, your required dosage
of this nutrient would be less since taking too many energy enhancing natural
pills can cause restlessness and insomnia. A carnitine
supplement is particularly helpful for vegetarians since it is found in only
small amounts in vegetables, fruits, and legumes.
L carnitine
benefits studies, how is it helpful?
L-carnitine was first isolated from the extracts of muscle tissue in
1905 by the employees of the department of medicinal chemistry at Moscow
University. Later the role of L-carnitine in both the oxidation of long chain
fatty acids and the metabolism of carbohydrates was discovered.
This supplement has potential as a treatment in several
conditions, but more research is needed to determine the appropriate dosage and
interactions with various other supplements and medications.
ADHD, attention deficit disorder
Treatment with carnitine decreased attention problems and aggressive behavior in boys with
ADHD.
Carnitine and acetyl l carnitine as anti-aging
supplements?
In addition to producing energy,
these two nutrients remove toxic accumulations of fatty acids from mitochondria,
keeping these organelles healthy and functioning at their best. Energy
production in mitochondria is not a perfect process and toxic metabolites
do accumulate. Accumulation of these toxic metabolites and the resulting
oxidative damage is likely to contribute to aging of cells. A waste substance
called lipofuscin accumulates in cells as we age and perhaps adequate acetyl-l carnitine
intake can help minimize this accumulation. A study in rats providing acetyl-l carnitine
from youth showed this nutrient to decrease lipofuscin levels in their brain as
they got old. Therefore, it is theoretically possible that supplementation with
either can slow the aging process.
Brain health research
Comparison of the effects of L-carnitine
and acetyl-L carnitine on carnitine levels, ambulatory activity, and oxidative
stress biomarkers in the brain of old rats.
Ann N Y Academy Science. 2004.
Aged rats were given each at 0.15% in drinking water for 4 weeks.
Both were
similar in elevating carnitine levels in plasma and brain. Both increased
ambulatory activity similarly. However, acetyl-L carnitine decreased the lipid
peroxidation in the old rat brain, while L-carnitine did not which indicates the
former may be a better supplement for brain health.
Cancer patients
Gan To Kagaku Ryoho. 2014. Experience with levocarnitine chloride
supplementation for the treatment of fatigue in cancer patients undergoing
chemotherapy. Ten patients with advanced and recurrent cancer experiencing
fatigue during chemotherapy were administered levocarnitine chloride. We
investigated changes in fatigue, and carried out nutritional assessment. Four
patients responded to levocarnitine chloride treatment, while six did not.
Cardiomyopathy
This condition has many causes and perhaps in a small number of cases carnitine
supplementation could be of benefit. However, I am not able to find much
research on this topic.
Eksp Klin Farmakol. 2014. Using L-carnitine to improve the adaptation of young athletes to physical load and the correction of stress-induced cardiomyopathy. Results of a comparative, parallel-group randomized clinical trial of L-carnitine (Elkar, PikFarma) in young athletes (football players, walkers) are reported. Elkar increases the body adaptation to physical stress and has a pronounced therapeutic effect in athletes with stress-induced cardiomyopathy by reducing the representation of potentially dangerous arrhythmia (sinus bradycardia less than 2 - 5 centile, 2nd degree atrioventricular block type II, T-wave inversion in more than 2 leads, and/or ST segment depression) and severity of benign ECG disturbances and hemodynamic changes, and decreasing the concentration of biochemical markers of myocardial damage (troponin, natriuretic peptide, creatine phosphokinase MB fraction) and cortisol. In general, Elkar contributed to a significant reduction in symptoms of cardiac remodeling in 75% of patients and had a weak effect in 25% of patents. It is concluded that the use of Elkar in playing sports and sports coaching quality of endurance is appropriate, especially in terms of myocardial remodeling.
Ann Cardiol Angeiol (Paris). 2014. A cause of dilated cardiomyopathy in a child: primary carnitine deficiency.
Acta Gastroenterol Belg.
2010. Dilated cardiomyopathy in celiac disease: role of carnitine deficiency.
Celiac disease (CD) is an immune-mediated enteropathy in genetically susceptible
persons and the disease can present with manifestations in the intestine and in
organs outside the gut. An increased prevalence of CD in patients with
idiopathic dilated cardiomyopathy or secondary cardiomyopathy and some other
cardiac disorders has been reported. Here is described a case of dilated
cardiomyopathy in a patient with CD and secondary carnitine deficiency. Dilated
cardiomyopathy due to carnitine deficiency may occur in CD patients and
carnitine deficiency may present not only at the time of diagnosis of CD but it
may also develop during gluten-free diet, particularly in patients with fast
weight gain and without carnitine supplementation.
For diabetic patients
Oral administration
reduces oxidized LDL cholesterol levels in patients with type 2
diabetes.
L-Carnitine supplementation reduces oxidized LDL cholesterol in patients
with diabetes.
American Journal of Clinical Nutrition, 2009.
Eighty-one patients with diabetes were
randomly assigned to 1 of 2 treatment groups for 3 months. The 2 groups received
either 2 grams once daily or placebo. At the end of the study period, the L-carnitine-treated
patients showed significant improvements compared with the placebo
group in the following markers: oxidized LDL levels decreased; LDL
cholesterol decreased; triglycerides decreased; apolipoprotein A1 concentrations
decreased; apolipoprotein B-100 concentrations decreased. Our study indicates
that oral administration
reduces oxidized LDL cholesterol levels in patients with type 2
diabetes.
Energy increase
Testimonial: I get the most wonderful 'feel good' and
energy when I take SAM-e 100mg and 150 mg of L-carnitine.
Exercise
Carnitine improves recovery after heavy
exercise and
may be of use in improving exercise capacity of people with peripheral
arterial disease. It moderately improves the duration of exercise and time to recovery in patients
with chronic stable angina.
J Nutr Sci. 2017. Utilisation of supplemented l-carnitine for fuel efficiency, as an antioxidant, and for muscle recovery in Labrador retrievers. The primary goal was to investigate the effects of l-carnitine on fuel efficiency, as an antioxidant, and for muscle recovery in Labrador retrievers. Dogs were split into two groups, with one group being supplemented with 250 mg/d of Carniking™ l-carnitine powder. Supplementing l-carnitine in the form of Carniking had positive benefits in Labrador retrievers for activity intensity, body composition, muscle recovery and oxidative capacity.
Fat metabolism
I live with chronic fatigue syndrome,
hypothyroidism, and depression. I would like to improve fat metabolism by
supplementing with L carnitine. However, acetyl l carnitine could also be very
useful for energy production. Will acetyl l carnitine improve fat metabolism as
well, or would I need to supplement with both to get the benefits they both
offer?
A. Both have some overlapping
functions. It is difficult to predict which one will be more effective and in
what dosage. A good option is to try each one by itself in varying dosages and
you can have a better understanding which one works for you better. Then you can
decide whether you wish to combine them.
Fatigue
benefit
Carnitine may improve fatigue in certain conditions,
including cancer patients receiving chemotherapy.
It decreases the severity and type of fatigue
induced by interferon-alpha in the treatment of patients with hepatitis C. Older individuals may
benefit from the use of this nutrient to enhance energy levels and wellbeing.
Supplements may benefit certain patients with fatigue
if there are no obvious causes, such iron deficiency anemia, a
serious medical condition, etc.
At 2 grams a day, it did not improve symptoms of fatigue in cancer patients compared to placebo. Journal of Clinical Oncology, online September 17, 2012. At least a quarter of the participants did not complete their follow-up assessment so it is not clear if this influenced the results. It is possible dosages above 500 mg could cause insomnia and thus the 2 grams that was given to the patients may have caused sleep disturbances and thus had a negative impact on energy levels. I would be interested to see a study using 250 mg or 500 mg.
Liver health
Sci Rep. 20175. Evaluation of the effects of L-carnitine on medaka (Oryzias
latipes) fatty liver. L-carnitine is a compound known to transport fatty acids
into the mitochondria to enhance β-oxidation-mediated metabolism of fats. In
this study, the effects of L-carnitine administration on fatty liver of medaka (Oryzias
latipes) were analysed, to check for disease improvement and metabolic changes.
Additionally, the effects of the concomitant administration of L-carnitine and
eicosapentaenoic acid (20:5n-3) (EPA) were investigated. Findings indicated
reduced lipid deposition, increase in metabolites associated with β-oxidation,
and significant reduction in fatty acid levels in the liver, implying
improvement in fatty liver condition. Concomitant administration of L-carnitine
and EPA resulted in further benefits.
Narcolepsy treatment
PLoS One. 2013. Effects of oral L-carnitine administration in
narcolepsy
patients: a randomized, double-blind, cross-over and placebo-controlled trial.
Narcolepsy is a sleep disorder characterized by excessive daytime sleepiness,
cataplexy, and rapid eye movement (REM) sleep abnormalities. To assess the
efficacy of oral L-carnitine for the treatment of narcolepsy, we performed a
clinical trial administering L-carnitine 510 mg/day to patients with the
disease. This study suggests that oral L-carnitine can be effective in reducing
excessive daytime sleepiness in narcolepsy patients.
Note: Some people may only require 250 mg a day whereas others may
need more than 500 mg.
Neurometabolic diseases
Gene. January 10 2014. L-carnitine supplementation as a potential
antioxidant therapy for inherited neurometabolic disorders.
Seniors and the elderly
Italian
researchers at the
University of Catania gave sixty-six centenarians 2 grams l
carnitine daily for six months. At the end of the study period, the treated
centenarians showed significant improvements in total fat mass and total muscle
mass. They were also less likely to have physical and mental fatigue. LDL-cholesterol
levels fell among the individuals taking the supplement. L-carnitine takers
gained 3.8 kilograms (8 pounds) of muscle mass, on average, and lost 1.8 kg (4
pounds) of fat mass. They were also able to walk 4 meters
further during a 6-minute walking test after treatment than those given placebo.
Comments: This study shows how much we still can learn about the
benefits of supplements in the aged. My preference would be to use a lower
amount, such as 250 mg or 500 mg. Sometimes when high dosages of
energy enhancing pills are taken for prolonged periods, they can accumulate and
interfere with sleep.
L-Carnitine treatment reduces severity of physical and mental fatigue
and increases cognitive functions in centenarians: a randomized and controlled
clinical trial
American Journal of Clinical Nutrition, 2007. Mariano Malaguarnera, Lisa Cammalleri, Maria Pia Gargante,. From the Department of
Senescence, Urological, and Neurological Sciences, University of Catania,
Catania, Italy
Sixty-six centenarians
with onset of fatigue after even slight physical activity were recruited
to the study. The 2 groups received either 2 grams l carnitine once daily
or placebo. The l carnitine treated centenarians, compared with
the placebo group, showed significant improvements in total fat mass,
total muscle mass, and plasma concentrations of total carnitine.
Significant differences were also found in physical fatigue and mental
fatigue.
Our study indicates that oral administration of l carnitine produces a
reduction of total fat mass, increases total muscular mass, and
facilitates an increased capacity for physical and cognitive activity by
reducing fatigue and improving cognitive functions.
L carnitine administration in elderly subjects with
rapid muscle fatigue: effect on body composition, lipid profile and fatigue.
Drugs Aging. 2003.
Eighty-four elderly subjects with onset of fatigue following
slight physical activity were recruited to the study. One group received carnitine 2g
twice daily and the other placebo. The treated patients
showed significant improvements in the following parameters: total fat mass,
total muscle mass, total cholesterol, LDL-C, HDL-C, triglycerides, apoA1, and apoB.
There was improvement in physical fatigue and mental fatigue. Administration of carnitine to healthy elderly subjects resulted in
a reduction of total fat mass, an increase of total muscle mass, and appeared to
exert a favourable effect on fatigue and serum lipids.
Fertility and sperm health
Carnitine and acetyl carnitine therapy are effective in increasing
fertility and
sperm-semen quality.
Several studies have shown improved sperm motility with
supplementation. Also consider the herb maca from
South America.
Combined treatment with L-carnitine, a popular dietary supplement, and acetyl-carnitine, a related chemical, appears to improve sperm motility in men with fertility problems. In the study, 60 infertile men between the ages of 20 and 40 years were randomly selected to take a combination of L-carnitine and L-acetyl-carnitine or an inactive "placebo" for 6 months. In the medical journal Fertility and Sterility, researchers at the University of Rome led by Dr. Andrea Lenzi report that 2 months after the completion of therapy, men who took these pills had increases in sperm concentration, forward movement, and total movement. The most significant improvements in sperm motility, both forward and total, were observed in men who had the lowest levels of moving sperm when the study began. The researchers note that four spontaneous pregnancies were achieved during the study by men who had taken the combination therapy.
Placebo-controlled double-blind randomized
trial on the use of L-carnitine, L-acetyl carnitine, or treatment in men with idiopathic asthenozoospermia.
Fertility & Sterility 2005.
Sixty infertile men, ages 20 to 40 years, with the following
baseline sperm selection criteria: concentration > 20 x 10(6)/mL, sperm forward
motility < 50%, and normal sperm morphology > 30%. Patients underwent a double-blind therapy of carnitine 3
grams a day, acetyl carntine 3 grams a day, a combination of carnitine 2 g/d and acetyl
carnitine 1 g/d, or placebo for a period of six months. Sperm cell
motility increased in patients to whom acetyl carnitine was administered both
alone or in combination with carnitine; combined
therapy led to a significant improvement of straight progressive velocity. The
combined administration is effective in increasing
sperm kinetic features in patients affected by idiopathic asthenozoospemia and
improves the total antioxidant status of the seminal fluid.
Heart health
Those with heart failure may benefit from carnitine supplements, but only small
amounts. There
have been some recent concerns that meat eaters may form an undesirable
substance called TMAO from
intake of high levels. There's a lot to investigate in the TMAO formation from
carnitine use before knowing if there are any risks involved.
I take L-Carnitine for my heart. Would the acetyl version be of more benefit or
should I stick with the former?
It is not possible to know in any individual person without knowing
the full medical history and exam. There are many other natural option for heart
health which are reviewed on the heart disease page.
Hormonal effect
Does it have
any hormonal effects such as gynecomastia or testicular atrophy in males?
We're not aware of any obvious hormonal effects with this
supplement,
but we have not seen any specific studies addressing this issue in humans for
any length of time.
Hyperthyroidism
Carnitine is effective in both reversing and preventing symptoms of hyperthyroidism and
has a beneficial effect on bone mineralization.
Because hyperthyroidism depletes the body deposits of
carnitine and since this supplement has little toxicity, teratogenicity, contraindications
and few interactions with drugs, carnitine can be of clinical use.
Kidney dialysis
Intravenous administration is an accepted pharmaceutical treatment for carnitine deficiency in
end-stage renal disease in patients undergoing dialysis.
Liver cirrhosis
Treatment of patients with liver cirrhosis with signs of
liver insufficiency is complex and seldom satisfactory. Carnitine is involved
in liver lipid metabolism and thus might be a potentially effective
nutrient. One study shows L carnitine lowers serum
ammonia concentration and improves lipid metabolism in patients with liver
cirrhosis. Carnitine may also play a beneficial role in the treatment of mild or
moderate hepatic encephalopathy, and perhaps liver cancer.
Liver cancer
L-carnitine inhibits
hepatocarcinogenesis via protection of mitochondria.
Int J Cancer. 2004.
Recently, we reported that mitochondrial dysfunction plays an important role in
liver cancer via the production of free radicals. Furthermore, we proved
that L-carnitine effectively protects mitochondrial function in vivo. Therefore,
we investigated whether long-term administration of L carnitine could prevent
hepatitis and subsequent hepatocellular carcinoma in Long-Evans Cinnamon rats
that are often analyzed as a model of hepatocarcinogenesis. The results
indicated that oxidative stress elicited from abnormally accumulated copper
increased the amount of free fatty acids, thereby inducing mitochondrial
dysfunction, resulting in cell death and enhanced secondary generation of
reactive oxygen species, which were significantly inhibited by carnitine
treatment. Mitochondrial
injury plays an essential role in the development of liver cancer and
the clinical use of carnitine may have therapeutic potential in
individuals with chronic hepatitis.
Sexual health
Apparently l carnitine is helpful in
sexual enhancement. Acetyl-l-carnitine is also helpful in this
regard. There are many herbs that are much more potent, including tribulus
terrestris, mucuna pruriens, maca, catuaba, yohimbe, and tongkat ali.
Weight loss
L carnitine may be an effective supplement for weight loss by itself, but when combined with other
nutrients it is even more effective.
The effect of l-carnitine on fat oxidation, protein turnover, and body
composition in slightly overweight subjects.
Metabolism. 2004.
We used a combined tracer technique with the stable isotopes
to gain further insight into the metabolic changes that accompany
supplementation of l-carnitine. The aim of the present study was to investigate
whether l-carnitine supplementation can influence fat oxidation, protein
turnover, body composition, and weight development in slightly overweight
subjects. Twelve volunteers received an individual regular diet either without
or with l-carnitine supplementation of 3 grams a day for 10 days. Body fat mass, total
body water, and lean body mass were calculated by using bioelectric impedance
analysis. L-carnitine supplementation led to a significant increase in protein synthesis indicating that
the increased dietary fat oxidation in slightly overweight subjects was not
accompanied by protein catabolism.
Caffeine, carnitine and choline supplementation of rats decreases body fat and serum leptin concentration as does exercise. J Nutr 2000.
Thalassemia
blood disorder
Effect of L-carnitine on the physical fitness of thalassemic patients.
Ann Hematol. 2007. El-Beshlawy A, El Accaoui R, Abd El-Sattar
M, Gamal El-Deen MH, Youssry I, Shaheen N.
Department of Pediatrics, New Children Hospital, Cairo University, Cairo, Egypt.
The main objective of this
study is to assess the effect of the administration of oral L-carnitine on
exercise tolerance and physical fitness in patients with thalassemia major.
Thirty patients followed up at the New Cairo University Children Hospital were
included in this study. Clinical, laboratory, and cardiopulmonary exercise
testing were performed before and after 6 months of oral L-carnitine therapy (50
mg per kg per day). The oxygen consumption, cardiac output, and oxygen pulse at
maximal exercise significantly increased after L-carnitine therapy. However,
there was no significant change in minute ventilation and ventilatory equivalent
of carbon dioxide. There was also significant increase in the blood transfusion
intervals after L-carnitine administration. However, there was no significant
change in hemoglobin concentration. L-Carnitine seems to be a safe and effective
adjunctive therapeutic approach in thalassemic patients. It improves their
cardiac performance and physical fitness. The younger the patients are, the
higher is the degree of improvement in their exercise parameters.
Comments: For long term use we suggest using a much lower dosage of
5 to 10 mg per kilogram body weight.
Thyroid medication
Is it safe to use these pills with thyroid therapy? I take
l carnitine before I exercise and as a recovery, but now that I'm on Synthroid
have read that it might affect the thyroid. I've also thought about trying
Armour thyroid but I want to continue my carnitine so am wondering if there is
any interactions with it and thryoid replacement therapies.
I have not seen specific studies with the combination of this
nutrient and thyroid hormone therapy. As a general rule, it is best to begin
with low dosages and be monitored with routine tests to see if there are any
effects. The response of different individuals may vary even if the same
combination is used so it is difficult to predict what would happen in any
individual.
L carnitine side effects, safety, danger, caution, risks
It seems l carnitine is a relatively safe nutrient in doses ranging from 50 to 500 mg.
Higher doses may lead to excess energy, restlessness, perhaps
insomnia. Long term side effects of high dose carnitine use are not fully known.
Q. I was interesting in taking it because I rarely eat meat.
I just read your page on it recommending 100 or so mg a few days a week, but I
also see that you sell it in 500 mg caps. It is hard to find any L-carnosine in
less mg than that. After ordering L-carnosine, I read some information that said
it depletes taurine and stores undesirable amounts of copper in the body/brain.
Do you know anything about that?
A. Currently the standard dosage that is made is 500 mg,
people can open a capsule and take a portion of it if they want to take it
regularly, but they can take 500 mg at one time if they just want to use it once
in a while. I have not seen human studies that indicate depletion of taurine or
storage of copper to be a concern, especially since I recommend low dosages with
breaks from use.
Side effect testimonial
I am a healthy 34 year old male (no real medical conditions or prescription drug
use) who has taken 500mg of Acetyl l Carnitine every morning for the past 10
years for great success and benefit with no bad side effects. A few months ago I
started taking a fertility supplement with L Carnitine as the active ingredient
(probably a few thousand mg daily). After 2 months of taking these supplements
together, I started experiencing overstimulation effects with faster pulse and
insomnia. I stopped taking both supplements over the past few weeks.
How does it work?
Deficiency
Metabolism
Carnitine, the L-beta-hydroxy-gamma-N-trimethylaminobutyric acid, is
synthesized primarily in the liver and kidneys from lysine and methionine.
Carnitine covers an important role in lipid metabolism, acting as an obligatory
cofactor for beta-oxidation of fatty acids by facilitating the transport of
long-chain fatty acids across the mitochondrial membrane as acylcarnitine
esters. Furthermore, since carnitine behaves as a shuttle for acetyl groups from
inside to outside the mitochondrial membrane, it covers a key role in
glucose metabolism and assists in fuel-sensing. A reduction of the fatty acid
transport inside the mitochondria results in the cytosolic accumulation of
triglycerides, which is implicated in the pathogenesis of insulin resistance.
Various forms are
available:
Raw material suppliers, such as Sigma Tau, have a wide variety of
products, including:
L-Carnitine Fumarate
Base USP, FCC, EP
Hydrochloride
Creatine Dihydrogen Phosphate
Hydrogen Fumarate Creatinate
Lysine L-Carnitine Fumarate Hydrochloride
Glycine Propionyl L-Carnitine Hydrochloride
L carnitine L
tartrate
There has not been enough research with each of these
forms to determine which is best for long term human consumption.
Free and total carnitine concentrations in pig plasma
after oral ingestion of various L carnitine compounds.
Int J Vitamin Nutrition Research. 2005.
This study was undertaken to investigate the bioavailability of various L
carnitine esters (acetyl L carnitine and lauroyl L carnitine) and salts (L
carnitine L tartrate, L carnitine fumarate, L carnitine magnesium citrate)
relative to base of free L carnitine. Six groups of five or six piglets each
were administered orally a single dose of 40 mg L carnitine equivalents/kg body
weight of each of those L carnitine compounds. AUC values, calculated for the time interval
between 0 and 32 hours, for both free and total carnitine were similar for base
of free L carnitine and the three L carnitine salts (L carnitine L tartrate, L
carnitine fumarate, L carnitine magnesium citrate) while those of the two esters
(acetyl L carnitine, lauroyl L carnitine) were lower. Administration of
Lcarnitine L tartrate yielded a higher plasma free carnitine AUC value for the
time interval between 0 and 3.5 hours than administration of the other
compounds. The data of this study suggest that L carnitine salts have a similar
bioavailability to that of free L carnitine while L carnitine esters have a
lower one. The study also suggests that L carnitine L tartrate is absorbed faster
than the other L carnitine compounds.
Propionyl l carnitine research
studies
Evaluation of the efficacy of propionyl-L-carnitine versus pulsed
muscular compressions in diabetic and non-diabetic patients affected by
obliterating arteriopathy Leriche stage II.
Int Angiol. 2008 June. Riccioni C, Sarcinella R, Palermo G, Izzo A, Liguori
M, Koverech A, Messano M, Virmani A. Complex Unit of Angiology, Nuovo Regina
Margherita Hospital, Rome, Italy.
The effectiveness of propionyl L carnitine (PLC) monotherapy regimen alone or in
association with pulsed muscular compression was compared to the physical
therapy by itself against obliterant arteriopathy Leriche Fontaine stage II.
PLC is involved in cellular metabolism and is transformed into
two active substances, free L-carnitine and propionyl-coenzyme A in the
mitochondria, which take part in fatty acid transfer and in the citric acid
cycle, respectively. Forty-two patients with arterial disease were selected (22
males and 20 females; mean age: 62+/-8 years; 21 type 2 diabetic [DB] and 21
non-DB [NDB]). Patients were randomized in three groups, each of them composed
by 14 patients (7 DB and 7 NDB): the first group was submitted to infusional
propionyl L carnitine therapy at a dosage of 4 fl (total: 1,200 mg PLC) in 250
cc of physiological solution for 5 days a week for 4 weeks; the second group was
treated with PLC in association with pulsed muscular compression therapy by
Vascupump; the third group was submitted only to Vascupump. From a subjective
point of view, patients referred benefits both in clinical terms, i.e. increased
walking distance and of decreased intensity of the calf pain. The instrumental parameters showed a trend
towards normality. Combined pharmaco- and physical therapy was most efficient
treatment regime and best results were seen in NDB compared to the DB patients.
Levo-propionyl-carnitine improves the effectiveness of
supervised physical training on the absolute claudication distance in patients
with intermittent claudication.
Angiology. 2008; Andreozzi GM, Leone A, Laudani R, Martin R, Deinit
G, Cataldi V. Angiology Care Unit of University Hospital of Padua, Italy.
Levo-propionylcarnitine increases the walking ability in claudicants, providing
an additional energy to the ischemic muscle. Therefore,
the current study was carried out to ascertain whether the combined treatment
has a synergistic effect. The results confirm the effectiveness of supervised
physical training in patients with IC, and we recommend the use of LPC during
the exercise training program, at least in patients with severe claudication.
Effect of glycine propionyl-L-carnitine on aerobic and
anaerobic exercise performance.
Int J Sport Nutr Exerc Metab. 2008; Smith WA, Fry AC, Tschume LC,
Bloomer RJ. Dept. of Health and Sport Sciences, University of Memphis, Memphis,
TN, USA.
The purpose of this study was to evaluate the effect of glycine
propionyl-L-carnitine (GPLC) supplementation and endurance training for 8 wk on
aerobic- and anaerobic-exercise performance in healthy men and women (age 18-44
yr). Participants were randomly assigned to 1 of 3 groups: placebo, 1 g/d GPLC, or 3 g/d GPLC, in a double-blind fashion. Muscle carnitine (vastus
lateralis), VO(2peak), exercise time to fatigue, anaerobic threshold, anaerobic
power, and total work were measured at baseline and after an 8-wk
aerobic-training program. There were no statistical differences between
or within the 3 groups for any performance-related variable or muscle carnitine
concentrations after 8 wk of supplementation and training. These results suggest
that up to 3 g/d GPLC for 8 wk in conjunction with aerobic-exercise training is
ineffective for increasing muscle carnitine content and has no significant
effects on aerobic- or anaerobic-exercise performance.
Testimonials
I am a 48 yr. female registered nurse from
New Zealand. I have been taking L- Carnitine 300mg for 7 days to assist in
weight loss after doing on-line research. Most of my 30 yr career in nursing has
been as an operating theatre nurse because of this I suffer from plantar fascitis, first in my left foot resulting in a bony spur then in my right foot -
no bony spur. This has been very painful, I have received many forms of
treatment from orthopaedic surgeon i.e.: steroid injection to podiatrist etc. It
has been very interesting to note that from Day 4 of taking L- carnitine that
the usual level of daily pain has lessened considerably to zero even.