Butea Superba herb extract for sexual enhancement and its use in aphrodisiac formulas, Also known as Red Kwao Krua
Research information, benefit and side effects
December 8 2016 by
Ray Sahelian, M.D.

Butea superba is a plant found in Thailand. Butea herb is used by middle aged and older Thai men as a tonic and for sexual enhancement. I have not come across any studies that butea superba cream or capsules lead to breast enlargement as some promoters claim. You will find this herb added to aphrodisiac herbal products for sexual enhancement purposes.

Mechanism of action, how it works
Very little Western research is available on butea. One study indicates that butea superba has some anticholinesterase activity. This would mean that it can increase levels of acetylcholine in the body. Acetylcholine is known to be involved with erectile function and memory. It could also have an influence on testosterone release but more research is needed.

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    Also consider additional natural products that improve libido and performance in a male and female. These include mucuna pruriens, tongkat ali, horny goat weed, tribulus terrestris, maca, catuaba, muira puama and yohimbe.

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Dr. Sahelian and his research staff have tested various doses and extracts of exotic herbs to determine the ideal dose and combination for optimal libido enhancement with fewest side effects. After years of experiments, a unique proprietary blend with more than a dozen herbal extracts, has been created. Passion Rx enhances sexual stamina, erectile function, orgasms and climaxes.Science has made many breakthroughs in the understanding of sexual dysfunction. But, for hundreds of years, civilizations around the world have known about locally grown herbs that achieve wonderful results with far fewer side effects than prescription drugs. Now, renowned physician and herbal expert Dr. Ray Sahelian, M.D., author of Natural Sex Boosters, has discovered a combination of exotic herbal extracts from the Amazon jungle, India, China, Malaysia, and Africa, that provides a natural solution for those seeking an alternative to synthetic drugs.
The potent herbal extracts in Passion Rx include ashwagandha herb, Catuaba herb, Cnidium herb, Coleus forskohlii herb with forskolin, Damiana herb, Horny goat weed with icariin, Maca extract, Passion flower extract, mucuna pruriens extract, muira puama herb, Suma herb, Rehmannia, rhodiola, Shilajit, Tribulus, and Tongkat Ali. A version of Passion Rx is available with yohimbe. Passion Rx does not have butea superba herbal extract at this time.

Benefits and properties, aphrodisiac, erectile dysfunction, sexual enhancement
Butea superba is used as a sexual enhancer in Asia, particularly Thailand to enhance sexual desire. One human trial shows it can improve erectile function in males (see below). Another study showed that when butea
herb (the frondosa koen species) was given to male rats, they mounted female rats more often and they also ejaculated more frequently.

Andrologia. 2011. Butea superba improves penile erection in diabetic rats. Our results suggest that the extract of B. superba enhanced penile erection in diabetic rats by increased blood flow as a result of the relaxation of the cavernous smooth muscle.

Clinical trial of Butea superba, an alternative herbal treatment for erectile dysfunction.
Asian J Andrology. 2003.
White Kwao Krua (Pueraria mirifica) is a Thai phytoestrogen-rich plant that has been used for a long time as an herbal medicine. The related plant, Red Kwao Krua (Butea superba), is abundantly distributed in the Thai deciduous forest and is popular among Thai males for the purpose of rejuvenation and increasing sexual vigor. The tuberous roots of Thai butea superba contain flavonoid and flavonoid glycoside with cAMP phosphodiesterase inhibitor activity as well as sterol compounds, including beta-sitosterol, campesterol and stigmasterol. However, the Indian Butea superba stem contains flavone glycoside and flavonol glycoside with no reports on its use for male sexual purposes. Butea superba contains a high cAMP phosphodiesterase inhibitor activity, which was directly related to corpus cavernosal vasodilation.
   To study the effect of Butea superba on erectile dysfunction in Thai males. A 3-month randomized double-blind clinical trial was carried out in volunteers with erectile dysfunction, aged 30 years approximately 70 years, to evaluate the therapeutic effect of the crude preparation of Butea superba tubers on erectile dysfunction. Estimation of the sexual record indicated that 82% of the patients exhibited noticeable improvement. Hematology and blood chemistry analysis revealed no apparent change. The plant preparation appears to improve the erectile function in impotence patients without apparent toxicity.

Butea superba improves penile erection in diabetic rats. Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. Andrologia. 2012.

Aphrodisiac activity of Butea frondosa extract in male rats.
Phytomedicine. 2004.
In the present study, the aphrodisiac activity of Butea frondonsa bark extract was investigated. The extract was administered orally by gavage for 28 days. Mount latency (ML), intromission latency (IL), ejaculation latency (EL), mounting frequency (MF), intromission frequency (IF), ejaculation frequency (EF) and post-ejaculatory interval (PEI) were the parameters observed before and during the sexual behavior study. The extract reduced significantly ML, IL, EL and PEI. The butea extract also increased significantly MF, IF and EF. These effects were observed in sexually active and inactive male rats.

Side effects of butea superba
Research in rodents does not indicate butea superba to have any significant side effects, but long term human studies are not yet available. In my experience, almost every sexual enhancing herb has a side effect when used in a high dosage.

The toxicology of Butea superba.
Southeast Asian J Trop Med Public Health. 2002.
A study to determine the primary toxicological effects of Red Gwow Kreur (Butea superba) dry powder by micronucleus and dominant lethal tests was undertaken. Aqueous solution of butea superba dry powder in doses of 2, 20, 200 and 1,000 mg / kg / day were fed to male rats for 9 weeks. The results showed that 1,000 mg / kg / day of butea superba solution was significantly more effective in inducing the formation of micronuclei in polychromatic erythrocytes than the control, whereas dominant lethal test indicated that none of the doses had a toxic effect on male reproduction. There were no abnormal changes in the number of implantation sites and the number of dead fetuses produced by females that had mated with butea superba treated males in comparison with the controls. In addition, the Red Gwow Kreur solutions had no effect on the body weights of the treated rats.

Hyperandrogenemia due to ingestion of Butea superba. Mahidol Nutrition Society, Mahidol University, Thailand. Indian J Endocrinol Metabolism. 2012.

Depression and mood
J Ethnopharmacology. 2014. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action.

Effects of Butea superba on reproductive systems of rats.
Fitoterapia. 2006. Pharmaceutical-Cosmetic Raw Materials and Natural Products Research and Development Center, Institute for Science and Technology Research and Development, Chiang Mai University, Thailand.
The effects of Butea superba on the reproductive system in male Wistar rats were investigated. The animals were fed daily with the powdered crude butea superba herb suspended in distilled water by a gastric tube at the dose of 2, 25, 250 and 1250 mg/kg body weight for 8 weeks. The weights of all vital organs in all treated groups were not different from the control. The percentage weight ratios of body weights of seminal vesicles and prostate glands were not different from the control, except that the testis of the group fed with 1250 mg/kg was significantly different from the control and the other treated groups. In addition, the sperm counts in this group showed about 16% more than the control group. Hematology as well as the liver and kidney function of all treated groups showed no difference from the control. Butea superba, drug at 250 mg/kg which was 100 times more than the Thai FDA recommended dose for humans appeared to be safe in rats. Butea superba herb increased testis weight and sperm counts.

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Antimicrobial properties
Compounds within butea superba have antimicrobial activity against several organisms.

Butea superba herb is sold as raw powder and in different potency extracts including a 4 to 1 extract and even as high as a 30 to 1 extract although it is not easy to know which companies products are reliable. Most often you will find it as part of sexual enhancing herbal formulas.

Research, breast cancer
The differential anti-proliferation effect of white Pueraria mirifica, red Butea superba, and black Mucuna collettii Kwao Krua plants on the growth of MCF-7 cells.
J Ethnopharmacol. 2004.
The differential anti-proliferation effect of white Pueraria mirifica, red Butea superba and black Mucuna collettii Kwao Krua plant extracts on the growth of MCF-7 cells was evaluated after 4 days of incubation. The results demonstrated that only butea superba showed an estrogenic effect on MCF-7 cell growth and a clear antagonistic effect with estrogen at high concentration. Butea superba and Mucuna collettii exhibited only anti-proliferation effects on the growth of MCF-7 cells in relation with a possible anti-estrogen mechanism or a potent cytotoxic effect.

Alzheimer's disease
Screening for acetylcholinesterase inhibitory activity in plants used in Thai traditional rejuvenating and neurotonic remedies.
J Ethnopharmacol. 2003.
Acetylcholinesterase (AChE) inhibitor has been used as a drug for the symptomatic treatment of Alzheimer's disease. In order to search for new AChE inhibitors, 32 plants used in Thai traditional rejuvenating and neurotonic remedies were collected. The results showed that the methanolic extracts from roots of Stephania suberosa Forman. and Tabernaemontana divaricata inhibited more than 90% of AChE activity. At the same concentration, four extracts, i.e. stems of Piper interruptum, seeds of Piper nigrum, rootbarks of Butea superba and roots of Cassia fistula extracts showed 50-65% inhibitory activity on AChE. The rest of the extracts showed the AChE inhibitory activity below 50%.

I tried lots of herbal products for sexual problems that did nothing, until I tried the butea superba. It works like the Passion Rx does in that you don't get the maximal effects for about a day or so. But, taking it every 2nd or 3rd day allowed me to perform at anytime. It was so much better than Viagra, no side effects.
     Same customer a few weeks later writes: We had a product up here called Bell Magnum Bullets, manufactured by a Canadian company that worked wonders for me. I was able to take one capsule every second day and it allowed me the spontaniety to be able to perform at anytime. The Canadian Gov't banned it saying that the product could be harmful to people who use nitrates, much the same way as Viagra. The manufacturer prompted legal action to keep the Bullets but of course the Gov't won out. I believe it was the butea that was alarming the Gov't. They said they did not have enough info on it, so they could not take any chances. What gained my attention to Passion Rx was the statement on your web page that said the effects were cumulative, and that it would build up in your system, much like the Bullets. I don't want anything that you have to "Time" before planned activity. I found the Bullets took about 8 hours to feel the desired effects, and it would last for a few days. With Passion Rx, it takes longer to kick in, but once it does, the libido effects are stronger. So, to compare, I liked the Bullets in that I knew in time of about 6-8 hours the effects would be there, and for over a day or so, but the libido feeling is stronger with Passion once it kicks in. I've done research on butea, and it is an herb, used for many years in Asia as an effective aphrodisiac, and proven safe as well. It's just that in the West, not enough research has been done.