Boldo herb, also known as Peumus boldus
June 6 2016 by Ray Sahelian, M.D.

Boldo is a tree or shrub that grows in the country of Chile in South America. Boldo has therapeutic potential in medicine.

What's in Boldo leaves?
The leaves of boldo herb contain alkaloids and essential oils including the alkaloid boldine and the essential oil ascaridole.

Health benefit of boldo herb
Boldo is a Chilean tree whose leaves have been used in folk medicine. Boldo leaves are rich in several aporphine-like alkaloids, of which boldine is the most abundant one. Boldine is a very potent antioxidant. There are claims that this herb has anti-tumor, anti-inflammatory, anti-diabetic and anti-atherogenic, and blood vessel relaxing potential.

J Integr Med. 2014. Low doses of ethanolic extract of Boldo (Peumus boldus) can ameliorate toxicity generated by cisplatin in normal liver cells of mice in vivo and in WRL-68 cells in vitro, but not in cancer cells in vivo or in vitro.

Transplant Proc. 2014. Case report: boldo (Peumus boldus) and tacrolimus interaction in a renal transplant patient. Boldo is an extract of a Chilean tree leave (Peumus boldus mol) that have been traditionally employed in folk medicine. We have presented a case of subtherapeutic tacrolimus levels in a renal transplant patient while taking boldo. In the literature search, no interaction has been reported between boldo and tacrolimus. We have reported a case of an allograft renal transplant recipient who presented to the clinic with subtherapeutic levels of tacrolimus while taking the herbal remedy boldo. Tacrolimus levels rose to the intended target after discontinuation of boldo. Although it is a single case report, our observation suggests a possible herb-drug interaction.