There are many species of this plant, including asparagus officinalis which has asparagosides. Asparagus racemosus is a member of the same family as the common asparagus. in Ayurvedic medicine it is commonly known as Shatavari. Asparagus extract supplement has been getting a lot of attention lately for its possible role in reducing hangover symptoms or to prevent liver damage from excess alcohol use. I am waiting for actual human studies to determine whether this product is beneficial for these conditions.
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Q. Which is better for you, asparagus capsules or eating the real
thing cooked?
A. It depends which health condition is being treated. They both
have benefits. It is not practical to eat asparagus shoots everyday so the
capsules can provide easy benefits by simply swallowing pills. One could at
times take a capsule and other times eat the vegetable.
Historical uses
Asparagus racemosus is
recommended in Ayurvedic texts for prevention and treatment of gastric
ulcers, dyspepsia and as a galactogogue - for the production of breast
milk in nursing mothers. It has also been
used successfully by some Ayurvedic practitioners for nervous disorders,
inflammation, liver diseases and certain infectious diseases.
Studies and research
I find few studies published in
the western medical literature regarding the use of root extract of
Asparagus racemosus in humans. Rare reports are
available demonstrating beneficial effects of alcoholic and water extracts
of the root of Asparagus racemosus in some clinical conditions and
experimentally induced diseases, e.g. galactogogue effect, antihepatotoxic
and immune modulating activities.
Hangover treatment or prevention? Does it work?
Asparagus leaves could help in the treatment of an alcohol hangover and also
protect the liver from the toxic results of alcohol. Liver damage is always a
concern for people who drink heavily. Korean researchers report that asparagus
leaves protect the liver from a number of toxic substances. The extract should
be taken prior to an evening of drinking because if it is taken after the liver
damage would already have been done. The study was conducted by researchers at
the Institute of Medical Science and Jeju National University in South Korea.
Antioxidant
Experimental excitotoxicity provokes oxidative damage in mice brain
and attenuation by extract of Asparagus racemosus.
J Neural Transm. 2004.
We designed this study to
investigate the potential of extract of Asparagus racemosus against kainic
acid (KA)-induced hippocampal and striatal neuronal damage. Extract of AR displayed
potent reductant of Fe(3+). The excitotoxic lesion in brain was produced
by intra-hippocampal and intra-striatal injections of kainic acid to
ketamine and xylazine anesthetized mice. The results showed impairment
of hippocampus and striatal regions of brain after KA injection marked by
an increase in lipid peroxidation and protein carbonyl content and decline
in glutathione peroxidase (GPx) activity and reduced glutathione (GSH)
content. The Asparagus racemosus extract supplemented mice displayed an
improvement in GPx activity and GSH content and reduction in membranal
lipid peroxidation and protein carbonyl.
Blood pressure
Does asparagus extract or fresh vegetable effect high blood pressure?
I have not seen any such studies in humans.
Cancer
Indian J Pharmacol. 2012. Shatavarins (containing Shatavarin IV) with
anticancer activity from the roots of Asparagus racemosus.
Asian Pac J Cancer Prev. 2014. Asparagus racemosus leaf extract inhibits growth of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3 fusion transcript inhibition and apoptosis independent cell death.
Diuretic
West Indian Med J. 2010.
Acute toxicity and diuretic studies of the roots of Asparagus racemosus in rats.
Asparagus racemosus has been used as diuretic in Ayurveda but has not been
validated by a suitable experimental model. The study was carried out with an
aqueous extract of the roots of Asparagus racemosus utilizing three doses viz
800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison
with standard drug (furosemide) and control (normal saline) rats after doing
acute toxicity study. Acute toxicity study showed no fatality even with the
highest dose. Asparagus racemosus showed diuretic activity at a 3200 mg/kg dose
without acute toxicity.
High blood pressure, hypertension
J Agric Food Chem. 2013. Green asparagus (Asparagus officinalis) prevented
hypertension by an inhibitory effect on angiotensin-converting enzyme activity
in the kidney of spontaneously hypertensive rats. Green asparagus (Asparagus
officinalis) is known to be rich in functional components. In the present study,
spontaneously hypertensive rats (SHR) were used to clarify whether green
asparagus prevents hypertension by inhibition of angiotensin-converting enzyme
(ACE) activity. Six-week-old male SHR were fed a diet with (AD group) or without
(ND group) 5% asparagus for 10 weeks. Systolic blood pressure (SBP), urinary
protein excretion/creatinine excretion, and ACE activity in the kidney were
significantly lower in the AD group compared with the ND group. Creatinine
clearance was significantly higher in the AD group compared with the ND group.
In addition, ACE inhibitory activity was observed in a boiling water extract of
asparagus. The ACE inhibitor purified and isolated from asparagus was identified
as 2″-hydroxynicotianamine. In conclusion, 2″-hydroxynicotianamine in asparagus
may be one of the factors inhibiting ACE activity in the kidney, thus preventing
hypertension and preserving renal function.
Immune enhancement
Immunoadjuvant potential of Asparagus racemosus aqueous extract in
experimental system.
J Ethnopharmacol. 2004.
The immunoadjuvant potential of Asparagus racemosus Family
aqueous root extract was evaluated in experimental animals immunized with
diphtheria, tetanus, pertussis (DTP) vaccine. Immune stimulation was
evaluated using serological and hematological parameters. Reduced mortality
accompanied with overall improved health status was observed in treated
animals after intra-cerebral challenge of B. pertussis indicating
development of protective immune response. Present study indicates
applications of test material as potential immunoadjuvant that also offers
direct therapeutic benefits resulting in less morbidity and mortality.
Kidney cancer prevention
Asian Pac J Cancer Prev. 2014. Asparagus racemosus leaf extract inhibits growth
of UOK 146 renal cell carcinoma cell line: simultaneous oncogenic PRCCTFE3
fusion transcript inhibition and apoptosis independent cell death.
Kidney stones prevention?
Study of antiurolithiatic activity of Asparagus racemosus on albino rats.
Indian J Pharmacol. 2012. Department of Pharmacology, S.V.S Medical College,
Mahabubnagar, Andhra Pradesh, India.
Thirty-six male Wistar albino rats were randomly divided into six groups. Ethylene glycol and ammonium chloride in drinking water were fed to all
groups (Groups II-VI) except normal control (Group I) rats for 10 days to induce urolithiasis. Group III-VI rats were treated with ethanolic extract of Asparagus
racemosus at doses 200, 400, 800, and 1600 mg/kg, respectively, for 10 days.
Positive control (Group II) rats were treated with EG/AC alone. Group I rats
were administered drinking water and distilled water (6 μl/g) by gavage. After
10 days, blood samples were collected and analyzed for serum concentrations of
calcium, phosphorus, urea, and creatinine. The kidneys were removed and
sectioned for histopathological examination. The rats treated with
ethanolic extract of A. racemosus at doses 800 and 1600 mg/ kg significantly
reduced the serum concentrations of calcium, phosphorus, urea, and creatinine.
Histopathology of the kidneys in Groups V and VI revealed less tissue damage and
were almost similar to Group I rats. The ethanolic extract of A.
racemosus has protective effect against
kidney stones.
Ulcer
treatment
Antisecretory and antiulcer activity of Asparagus racemosus against indomethacin plus phyloric ligation-induced gastric
ulcer in rats.
J Herb Pharmacother. 2006. Department of Zoology, University College of Science, MLS University,
Udaipur, India.
Drs Bhatnagar and Sisodia studied the antisecretory and antiulcer activity
of Asparagus racemosus methanolic extract and its
action against indomethacin (a non-steroidal anti-inflammatory drug) plus
pyloric ligation (PL)-induced gastric ulcers in rats. Treatment with
Asparagus racemosus crude extract (100 mg/kg/day orally) for fifteen days
significantly reduced ulcer index when compared with control group.
Asparagus racemosus was found to be an effective antiulcerogenic agent,
whose activity can well be compared with that of ranitidine hydrochloride.
The results of this study suggest that Asparagus racemosus causes an
inhibitory effect on release of gastric hydrochloric acid and protects
gastric mucosal damage.
Side effects, safety
I have not yet come across
reports of asparagus extract side effects.
Review article
Nat Prod Res. 2016. Asparagus racemosus: a review on its phytochemical
and therapeutic potential. Asparagus racemosus is a widely found
medicinal plant in tropical and subtropical parts of India. The
therapeutic applications of this plant have been reported in Indian and
British Pharmacopoeias and in traditional system of medicine, such as
Ayurveda, Unani and Siddha. The crude, semi-purified and purified
extracts obtained from different parts of this plant have been useful in
therapeutic applications. Numerous bioactive phytochemicals mostly
saponins and flavonoids have been isolated and identified from this
plant which are responsible alone or in combination for various
pharmacological activities. This review aims to give a comprehensive
overview of traditional applications, current knowledge on the
phytochemistry, pharmacology and overuse of A. racemosus.
Laboratory studies
Asparagus racemosus on mammary gland and
genital organs
Effect of Asparagus
racemosus rhizome on mammary gland and genital organs of
pregnant rat.
Phytother Res. 2005.
Department of Anatomy, Institute of Medical Sciences, Banaras Hindu
University, Varanasi, India.
The alcoholic extract of its rhizome was administered orally to
adult pregnant female albino rats at a dose of 30 mg/100 g body weight,
daily for 15 days (days 1-15 of gestation). The macroscopic findings
revealed a prominence of the mammary glands, a dilated vaginal opening
and a transversely situated uterine horn in the treated group of
animals. Our results
suggest an estrogenic effect of Shatavari on the female mammary gland and
genital organs.
Asparagus gobicus
Nor-lignans and steroidal saponins from Asparagus gobicus.
Planta Med. 2004.
From the roots of Asparagus gobicus, four new nor-lignans,
3'-methoxynyasin, iso-agatharesinol, gobicusins A, B and one new steroidal
saponin,
3-O-[beta-D-xylopyranosyl(1-4)-beta-D-glucopyranosyl(1-2)-beta-D-glucopyranosyl]-(25S)-5beta-spirostan-3beta-ol
(11) were isolated, together with twelve known compounds. Some exhibited remarkable in vitro cytotoxic activity against
cultured HO-8910 (human ovarian carcinoma) and Bel-7402 (human hepatoma)
cells.
Asparagus cochinchinensis
chemicals
Bioactive constituents from Asparagus cochinchinensis.
J Nat Prod. 2004.
Bioassay-directed fractionation of the dried roots of Asparagus
cochinchinensis led to the isolation of a new spirostanol saponin,
asparacoside, two new C-27 spirosteroids, asparacosins A and B, a new acetylenic derivative, 3' '-methoxyasparenydiol, and a new polyphenol, 3'-hydroxy-4'-methoxy-4'-dehydroxynyasol, as well as five
known phenolic compounds, asparenydiol, nyasol, 3' '-methoxynyasol, and trans-coniferyl
alcohol.
Combining with other
supplements
Can an asparagus supplement be taken the same day as mangosteen or
lipoic acid supplements?
I don't see why not.
How is it available?
Asparagus Root Extract 4% to 10 percent asparagoside is sold by
raw material ingredient suppliers.
Emails, Testimonial
I am a student at a university in San Antonio, TX as well as a regular consumer
of your asparagus extract (200 mg, 10:1 Pure). I use it when I consume alcohol
in reasonable quantities to help me reduce the alcohol-induced damage to my
body. I find your product to be superior to a lot of extracts that I have tried.
Other products available online
Enzymatic Therapy, Asparagus Extract, 60 Veggie
Caps
Supplement Facts | ||
Serving Size: 1 capsule | ||
Amount Per Capsule | %Daily Value | |
Asparagus (Asparagus officinalis), Rhizome Extract | 170 mg | ** |
**Daily Value not established. |
Recommendations and dosage: One asparagus capsule in the morning and lunch or as
recommended by your doctor.
Supplement Facts:
Serving Size 1 capsule
Asparagus officinalis 170 mg each pill, Rhizome Extract
Other products online
Savesta, Shatavari, 60 Veggie Caps
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