Ascorbic acid is required for the growth and repair
of tissues. it is necessary to form
collagen, an important
protein used to make skin, scar tissue, tendons, ligaments, and blood
vessels. This nutrient is also essential for the healing of wounds, and
for the repair and maintenance of cartilage, bones, and teeth.
Availability of ascorbic acid supplement
Countless products and formulas are sold either as
single ingredients or combined in a multivitamin formula. Ascorbic
acid comes by itself in dosage ranging from 100 to 1000 mg, it comes as
powder, as Ester C, mixed in
multivitamin formulas,
and combined with rose hips, etc.
MultiVit Rx high Quality Daily Vitamins and Minerals with
daily requirement of ascorbic acid and
rose hips - 500 mg
This
MultiVit Rx product
has 500 mg of ascorbic acid and rose hips per daily dose.
Dosage and use: It is not necessary to take a pill daily. A 500 mg dose
a few times a week is sufficient.
Benefits, how it helps
Brain cell protection, nerve cell protection
Biochem Biophys Res Commun. 2014. Ascorbic acid prevents high
glucose-induced apoptosis in human brain pericytes. High glucose
concentrations due to diabetes increase apoptosis of vascular pericytes,
impairing vascular regulation and weakening vessels, especially in brain
and retina.
Ascorbic Acid in Cosmetics
Ascorbic acid and Pregnancy
Ascorbic acid
supplementation to prevent premature rupture of the chorioamniotic
membranes: a randomized trial.
American J Clinical Nutr. 2005.
Public Health Research Branch, National Institute of Perinatology, Mexico
City, Mexico.
Ascorbic acid is involved in the synthesis and degradation of collagen
and is important for maintenance of the chorioamniotic membranes.
Inadequate availability of ascorbic acid during pregnancy has been
proposed as a risk factor for premature rupture of the chorioamniotic
membranes (PROM). The objective of the study was to evaluate the
effectiveness of 100 mg ascorbic acid per day in preventing PROM. A
controlled double-blind trial was performed. Pregnant women (n = 126) in
their 20th wk of gestation were invited; 120 accepted and were randomly
assigned to 2 groups (100 mg ascorbic acid or placebo). Every 4 wk, plasma
and leukocyte ascorbic acid concentrations were measured, and each subject
was evaluated for cervicovaginal infection. The incidence of PROM was
recorded for each group as an indicator of the protective effect of
ascorbic acid supplementation. One hundred nine patients finished
the study. Mean plasma ascorbic acid concentrations decreased
significantly throughout the pregnancy in both groups, and there were no
significant differences between groups. Between weeks 20 and 36, mean
leukocyte ascorbic acid concentrations decreased from 17 to 15 microg/10(8)
cells in the placebo group and increased from 17 to 22 microg/10(8)
cells in the supplemented group (within- and between-group differences.
The incidence of PROM was 14 per 57 pregnancies (24%) in the placebo group
and 4 per 52 pregnancies (7%) in the supplemented group. Daily
supplementation with 100 mg vitamin C after 20 wk of gestation effectively
lessens the incidence of PROM. l ascorbic acid
J Obstet Gynaecol India. 2014 Dec. Ascorbic Acid concentration and preterm premature rupture of membranes. Ascorbic acid concentration was low in women with PPROM. Thus, vitamin C supplementation should be made mandatory along with iron and calcium to antenatal women to avoid the complications of PPROM.
Heart disease and attack
Antioxidant effects of combined vitamins C and E
in acute myocardial infarction. The randomized, double-blind, placebo
controlled, multicenter pilot Myocardial Infarction and VITamins (MIVIT)
trial.
Kardiol Pol. 2005.
There is a large body of evidence that reactive oxygen species (ROS)
produced during myocardial ischemia and reperfusion play a crucial role in
myocardial damage and endothelial dysfunction. The MIVIT pilot trial was
designed to test the effects of antioxidant ascorbic acid and vitamin E on
the clinical outcome of patients with AMI. In this
randomized, double-blind, multicenter trial, 800 patients (mean age 62)
with AMI were randomly allocated to receive, on top of routine medication,
one of two treatments: ascorbic acid (1000 mg/12 h infusion) followed by
1200 mg/24 h orally and vitamin E (600 mg/24 h) or matching placebo for 30
days. Primary end point (composite of in-hospital cardiac mortality,
non-fatal new myocardial infarction, VT/VF/ asystole, shock / pulmonary
edema) occurred less frequently in patients treated with antioxidants.
This randomized pilot trial shows that supplementation with
antioxidant vitamins ascorbic acid and vitamin E is safe and seems to
positively influence the clinical outcome of patients with AMI.
Ascorbic Acid Research, side effects
Ascorbate increases human oxaluria and
kidney
stone risk.
J Nutr. 2005. Department of Food Science and Human Nutrition, Washington State
University, Spokane, WA
Currently, the recommended upper limit for ascorbic acid intake is 2000
mg/d. However, because ascorbic acid is endogenously converted to oxalate
and appears to increase the absorption of dietary oxalate, supplementation
may increase the risk of kidney stones. The effect of ascorbic acid
supplementation on urinary oxalate was studied in a randomized, crossover,
controlled design in which subjects consumed a controlled diet in a
university metabolic unit. Stoneformers (n = 29; SF) and age- and
gender-matched non-stoneformers (n = 19; NSF) consumed 1000 mg ascorbic
acid twice each day with each morning and evening meal for 6 d (treatment
A), and no ascorbic acid for 6 d (treatment N) in random order. After 5 d
of adaptation to a low-oxalate diet, participants lived for 24 h in a
metabolic unit, during which they were given 136 mg oxalate, including 18
mg 13C2 oxalic acid, 2 h before breakfast; they then consumed a controlled
very low-oxalate diet for 24 h. Of the 48 participants, 19 (12
stoneformers, 7 non-stoneformers) were identified as responders, defined
by an increase in 24-h total oxalate excretion > 10% after treatment A
compared with N. Responders had a greater 24-h Tiselius Risk Index (TRI)
with AA supplementation because of a 31% increase in the percentage of
oxalate absorption and a 39% increase in endogenous oxalate synthesis with
treatment A than during treatment N. The 1000 mg ascorbic acid twice each
day increased urinary oxalate and TRI for calcium oxalate kidney stones in
40% of participants, both stoneformers and non-stoneformers. vitamin c ascorbic acid.
Emails
Q. Is
erythorbic acid the same as ascorbic acid?
A. Erythorbic acid is a stereoisomer of ascorbic acid
with similar properties.
Interactions, combinations
Q. Can ascorbic acid be taken the same day as
vinpocetine?
A. We don't see any reason why not.
I've heard good things about
resveratrol.
Would it interact with ascorbic acid in a bad way if I took them both
together?
I have not seen any indication that it would.
Where to buy
Q. I wish to purchase 2 to 4 oz of L ascorbic acid
crystals.
A. The best way is to do a google search since we are
not familiar with a liquid ascorbic acid crystals product .
Is l-ascorbic acid exactly the same thing as ascorbic acid? I need
to purchase some.
Both are the same as far as when
mentioned on a supplement bottle label.