Abuta herb Cissampelos pareira herb
August 20 2017 by Ray Sahelian, M.D.

Abuta is a plant from the Amazon forest. Locals use it as a tonic and for several health conditions. Abuta is used South America to prevent a threatened miscarriage and to stop uterine hemorrhages after childbirth. Also known as Laghupatha, it is an important medicinal plant in Indian traditional system of medicine and is widely used in many countries by different tribes. Despite its wide use in folk medicine, no study has been published regarding its use in humans in the scientific literature.

Abuta antioxidants and substances
Abuta has antioxidant properties and can help the body maintain antioxidant enzyme levels of superoxide dismutase and catalase. Abuta contains numerous compounds including a chalcone-flavone dimer named cissampeloflavone, alkaloids such as hayatinin methochloride, Pareirubrines A and B, grandirubrine, isoimerubrine, and cissampareine.

Availability of the herb
Abuta is sold either in capsules or as a liquid extract.

Research, studies
No human research with abuta root or vine could be found as of 2017.

Rodent studies
Abuta has been helpful to treat arthritis symptoms and has been found to have anti-inflammatory activity.

Abuta species
I've seen it
advertised by a raw material supplier as Abuta grandifolia. I am not sure how different abuta gradifolia is from cissampelos pareira.

Composition, what's in it?
A chalcone flavone called cissampeloflavone has been isolated from the herb. Tropoloisoquinoline alkaloids, Pareirubrines A and B, have been isolated, together with the same skeleton alkaloids, grandirubrine and isoimerubrine. Hayatinin methochloride is another alkaloid.
   The roots contain protoberberine alkaloids, hayatidin and hayatin.

Abuta research studies
Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice.
J Ethnopharmacology. 2007. Department of Chemistry, Cotton College, Guwahati, Assam, India.
Meenakshi Cissampelos pareira is one of the folk medicinal plants commonly used as antifertility agent in some places of India. The aim of the present study was to evaluate the validity of the antifertility effect of the leaf extract. Cissampelos pareira leaf extract, when administered orally, altered the estrous cycle pattern in female mice, prolonged the length of estrous cycle with significant increase in the duration of diestrus stage and reduced significantly the number of litters in albino mice. The plant extract altered gonadotropin release (LH, FSH and prolactin) and estradiol secretion.

Fitoterapia. 2012. New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia. The phytochemical study of the stem bark and wood of Abuta grandifolia (Mart.) Sandwith led to the identification of four bisbenzylisoquinoline alkaloids (BBIQs), namely (R,S)-2 N-norberbamunine (1), (R,R)-isochondodendrine (2), (S-S)-O4″-methyl, Nb-nor-O6'-demethyl-(+)-curine (3), and (S-S)-O4″-methyl, O6'-demethyl-(+)-curine (4), together with the aporphine alkaloid R-nornuciferine (5), all obtained by countercurrent distribution separation (CCD) and identified on the basis of their spectroscopic data. Alkaloids 3 and 4 were new. All the isolated compounds were tested for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities. 1 was the most active against AChE, whereas 3 and 4 were the most potent against BChE. Interestingly, all tested alkaloids are more potent against BChE than against AChE. This selectivity of cholinesterase (ChE) inhibition could be important in order to speculate on their potential therapeutic relevance.

Interactions with herbs
Can abuta herb be taken the same day as Yohimbe Bark extract?
   We don't know for sure, but yohimbe bark is potent and care must be taken to use a small amount only and not to mix it with other herbs if possible, particularly in high doses.